Literature DB >> 10375606

Analysis of Bcl-2, Bax and Survivin genes in uterine cancer.

Y Saitoh1, Y Yaginuma, M Ishikawa.   

Abstract

To investigate the role of the apoptosis-related genes, Bcl-2, Bax and Survivin genes were analyzed. For the Bax gene, abnormality was detected in 1 of 7 cervical and 1 of 6 endometrial cancer cell lines, 1 of 25 cervical cancer tissues and none of 17 endometrial cancer tissues using PCR-SSCP. In 4 cervical and 2 endometrial cancer cell lines, the ratio of Bcl-2 to Bax expression was higher than the control ratio using Western blotting. Survivin mRNA was detectable in all cell lines and all cancer tissues. The data suggested that these apoptosis-related genes may play important roles in the pathway of carcinogenesis of human uterine cancer.

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Year:  1999        PMID： 10375606     DOI： 10.3892/ijo.15.1.137

Source DB:  PubMed          Journal:  Int J Oncol        ISSN： 1019-6439            Impact factor:   5.650


  10 in total

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Journal:  Eur J Hum Genet       Date:  2012-01-25       Impact factor: 4.246

2.  Survivin antisense compound inhibits proliferation and promotes apoptosis in liver cancer cells.

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5.  Qingjie Fuzheng Granules regulates cancer cell proliferation, apoptosis and tumor angiogenesis in colorectal cancer xenograft mice via Sonic Hedgehog pathway.

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6.  Expression of matrix metalloproteinase-2 and survivin in endometrioid and nonendometrioid endometrial cancers and clinicopathologic significance.

Authors:  Evren Yilmaz; Meral Koyuncuoglu; Ilknur Bilkay Görken; Emre Okyay; Bahadir Saatli; Emine Cagnur Ulukus; Ugur Saygili
Journal:  J Gynecol Oncol       Date:  2011-06-30       Impact factor: 4.401

7.  Survivin expression in in situ and invasive breast cancer relates to COX-2 expression and DCIS recurrence.

Authors:  N Barnes; P Haywood; P Flint; W F Knox; N J Bundred
Journal:  Br J Cancer       Date:  2006-01-30       Impact factor: 7.640

8.  Survivin-targeting Artificial MicroRNAs Mediated by Adenovirus Suppress Tumor Activity in Cancer Cells and Xenograft Models.

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Journal:  Mol Ther Nucleic Acids       Date:  2014-11-04       Impact factor: 10.183

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10.  Role of IAPs in prostate cancer progression: immunohistochemical study in normal and pathological (benign hyperplastic, prostatic intraepithelial neoplasia and cancer) human prostate.

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Journal:  BMC Cancer       Date:  2010-01-15       Impact factor: 4.430
  10 in total

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