Literature DB >> 10375524

HIV: a new role for Nef in the spread of HIV.

M Harris1.   

Abstract

The HIV Nef protein downregulates the cell-surface expression of the HIV receptor glycoprotein CD4, but the significance of this event has remained obscure. Recent data suggest that Nef reduces cell-surface CD4 to promote the efficient spread of the virus.

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Year:  1999        PMID： 10375524     DOI： 10.1016/s0960-9822(99)80282-6

Source DB:  PubMed          Journal:  Curr Biol        ISSN： 0960-9822            Impact factor:   10.834


  14 in total

1.  Mutation of a conserved residue (D123) required for oligomerization of human immunodeficiency virus type 1 Nef protein abolishes interaction with human thioesterase and results in impairment of Nef biological functions.

Authors:  L X Liu; N Heveker; O T Fackler; S Arold; S Le Gall; K Janvier; B M Peterlin; C Dumas; O Schwartz; S Benichou; R Benarous
Journal:  J Virol       Date:  2000-06       Impact factor: 5.103

2.  Human immunodeficiency virus type 1 Nef functions at the level of virus entry by enhancing cytoplasmic delivery of virions.

Authors:  E Schaeffer; R Geleziunas; W C Greene
Journal:  J Virol       Date:  2001-03       Impact factor: 5.103

3.  CD4 and MHC-I downregulation are conserved in primary HIV-1 Nef alleles from brain and lymphoid tissues, but Pak2 activation is highly variable.

Authors:  Kristin Agopian; Bangdong L Wei; J Victor Garcia; Dana Gabuzda
Journal:  Virology       Date:  2006-09-18       Impact factor: 3.616

4.  A Novel HIV-1 Nef Mutation in a Primary Pediatric Isolate Impairs MHC-Class I Downregulation and Cytopathicity.

Authors:  Ayub Ali; Robert L Furler; Livia Pedroza-Martins; Arnaud D Colantonio; Deborah Anisman-Posner; Yvonne Bryson; Otto O Yang; Christel H Uittenbogaart
Journal:  AIDS Res Hum Retroviruses       Date:  2019-11-04       Impact factor: 2.205

5.  Direct in vitro binding of full-length human immunodeficiency virus type 1 Nef protein to CD4 cytoplasmic domain.

Authors:  A Preusser; L Briese; A S Baur; D Willbold
Journal:  J Virol       Date:  2001-04       Impact factor: 5.103

6.  The pathogenicity of human immunodeficiency virus (HIV) type 1 Nef in CD4C/HIV transgenic mice is abolished by mutation of its SH3-binding domain, and disease development is delayed in the absence of Hck.

Authors:  Z Hanna; X Weng; D G Kay; J Poudrier; C Lowell; P Jolicoeur
Journal:  J Virol       Date:  2001-10       Impact factor: 5.103

7.  Inhibition of human immunodeficiency virus type 1 by triciribine involves the accessory protein nef.

Authors:  Roger G Ptak; Brian G Gentry; Tracy L Hartman; Karen M Watson; M Clayton Osterling; Robert W Buckheit; Leroy B Townsend; John C Drach
Journal:  Antimicrob Agents Chemother       Date:  2010-01-19       Impact factor: 5.191

8.  CD4+ T cells from CD4C/HIVNef transgenic mice show enhanced activation in vivo with impaired proliferation in vitro but are dispensable for the development of a severe AIDS-like organ disease.

Authors:  Xiaoduan Weng; Elena Priceputu; Pavel Chrobak; Johanne Poudrier; Denis G Kay; Zaher Hanna; Tak W Mak; Paul Jolicoeur
Journal:  J Virol       Date:  2004-05       Impact factor: 5.103

Review 9.  Interactions of HIV and methamphetamine: cellular and molecular mechanisms of toxicity potentiation.

Authors:  J L Cadet; I N Krasnova
Journal:  Neurotox Res       Date:  2007-10       Impact factor: 3.911

Review 10.  HIV-1, reactive oxygen species, and vascular complications.

Authors:  Kristi M Porter; Roy L Sutliff
Journal:  Free Radic Biol Med       Date:  2012-04-21       Impact factor: 7.376
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