Literature DB >> 10375386

Detection of pathological zinc accumulation in neurons: methods for autopsy, biopsy, and cultured tissue.

S W Suh1, K Listiack, B Bell, J Chen, M Motamedi, D Silva, G Danscher, W Whetsell, R Thompson, C Frederickson.   

Abstract

It has been repeatedly shown that synaptically released zinc contributes to excitotoxic neuronal injury in ischemia, epilepsy, and mechanical head trauma. Such zinc-induced injury leaves an unmistakable "footprint" in the injured neurons, allowing an easy and unambiguous postmortem diagnosis. This footprint is the presence of weakly bound, histochemically reactive zinc in the cytoplasm of the perikaryon and proximal dendrites. Such staining appears to be a necessary and sufficient marker for zinc-induced neuronal injury. Here we show how to prepare and stain tissue from biopsy, autopsy, or experimental animal sources for maximal contrast and visibility of zinc-injured neurons.

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Year:  1999        PMID： 10375386     DOI： 10.1177/002215549904700715

Source DB:  PubMed          Journal:  J Histochem Cytochem        ISSN： 0022-1554            Impact factor:   2.479


  9 in total

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2.  Selective, quantitative measurement of releasable synaptic zinc in human autopsy hippocampal brain tissue from Alzheimer's disease patients.

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Review 5.  Axonal transport of zinc transporter 3 and zinc containing organelles in the rodent adrenergic system.

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Review 8.  Zinc in the Brain: Friend or Foe?

Authors:  Seunghyuk Choi; Dae Ki Hong; Bo Young Choi; Sang Won Suh
Journal:  Int J Mol Sci       Date:  2020-11-25       Impact factor: 5.923

9.  A Novel Zinc Chelator, 1H10, Ameliorates Experimental Autoimmune Encephalomyelitis by Modulating Zinc Toxicity and AMPK Activation.

Authors:  Bo Young Choi; Jeong Hyun Jeong; Jae-Won Eom; Jae-Young Koh; Yang-Hee Kim; Sang Won Suh
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  9 in total

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