R Zhu1, S Kang, D Wu. 1. Department of Pathology, First Hospital Affiliated to Suzhou Medical College.
Abstract
OBJECTIVE: To realize the significance of c-erbB1 and c-myc protooncogenes, p53 and p16 tumor suppressor genes in the development and pathologic diagnosis of human glioma. METHODS: The expression of p53, c-erbB1, c-myc and p16 gene proteins was detected immunohistochemically in 65 cases of glioma. The relationship between these results and the pathological grades was determined. RESULTS: The overexpression of mutant p53, c-erbB1 and c-myc was in accordance with the increasing grade of glioma malignancy, showing significant difference (P < 0.05) between the benign group and highly malignant group in p53 and c-erbB1, while the deletion of p16 protein was more frequent in the highly malignant group than in any other group. These 4 genes showed co-expression in some of the gliomas. CONCLUSIONS: The 4 genes, especially p53 and c-erbB1, play an important role in the development of glioma; the detection of these gene proteins has a positive significance on malignancy determination for glioma.
OBJECTIVE: To realize the significance of c-erbB1 and c-myc protooncogenes, p53 and p16tumor suppressor genes in the development and pathologic diagnosis of humanglioma. METHODS: The expression of p53, c-erbB1, c-myc and p16 gene proteins was detected immunohistochemically in 65 cases of glioma. The relationship between these results and the pathological grades was determined. RESULTS: The overexpression of mutant p53, c-erbB1 and c-myc was in accordance with the increasing grade of glioma malignancy, showing significant difference (P < 0.05) between the benign group and highly malignant group in p53 and c-erbB1, while the deletion of p16 protein was more frequent in the highly malignant group than in any other group. These 4 genes showed co-expression in some of the gliomas. CONCLUSIONS: The 4 genes, especially p53 and c-erbB1, play an important role in the development of glioma; the detection of these gene proteins has a positive significance on malignancy determination for glioma.