| Literature DB >> 10373641 |
T Inoue1, M Yashiro, S Nishimura, K Maeda, T Sawada, Y Ogawa, M Sowa, K H Chung.
Abstract
Proteolytic activity of cancer cells is an important factor in metastasis. This study examined the relationship between MMP-1 expression of gastric cancer cells and peritoneal metastasis. MMP-1 expression was found in 76/103 (75.2%) cases examined and was significantly associated with both peritoneal metastasis and lymph node metastasis (p<0.05, respectively). The prognosis of patients with MMP-1 positive tumor was significantly worse than that of patients with MMP-1 negative tumor (p<0.05). These findings suggested that MMP-1 might be a prognostic factor in case of advanced gastric cancer and might be useful in determining whether or not adjuvant therapy was indicated for patients at high risk of peritoneal recurrence.Entities:
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Year: 1999 PMID： 10373641 DOI： 10.3892/ijmm.4.1.73
Source DB: PubMed Journal: Int J Mol Med ISSN： 1107-3756 Impact factor: 4.101