| Literature DB >> 10373320 |
T K Watanabe1, S Okuno, K Oga, A Mizoguchi-Miyakita, A Tsuji, Y Yamasaki, H Hishigaki, N Kanemoto, T Takagi, E Takahashi, Y Irie, Y Nakamura, A Tanigami.
Abstract
To identify genetic determinants relevant to non-insulin-dependent diabetes mellitus (NIDDM), we performed a genome-wide analysis for quantitative trait loci (QTLs) using 359 backcross progeny of the Otsuka Long-Evans Tokushima Fatty (OLETF) rat. The OLETF strain is a well-studied animal model of obese NIDDM, with features of hyperinsulinemia, hyperglycemia, insulin resistance, and abundant abdominal fat. Our extensive genomic scanning with 218 markers revealed nine significant QTLs, including a strong determinant of obesity on chromosome 1 (Dmo1: LOD = 13.99, for body weight). Two highly significant QTLs for glucose homeostasis were found, one on chromosome 1 (Dmo4 LOD = 7.16, for postprandial glucose level) and the other on chromosome X (Dmo11/Odb1: LOD = 7.81, for postprandial glucose level). These data are comparable to results of our previous studies of the OLETF rat. Copyright 1999 Academic Press.Entities:
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Year: 1999 PMID： 10373320 DOI： 10.1006/geno.1999.5789
Source DB: PubMed Journal: Genomics ISSN： 0888-7543 Impact factor: 5.736