Literature DB >> 10373118

Requirement for croquemort in phagocytosis of apoptotic cells in Drosophila.

N C Franc1, P Heitzler, R A Ezekowitz, K White.   

Abstract

Macrophages in the Drosophila embryo are responsible for the phagocytosis of apoptotic cells and are competent to engulf bacteria. Croquemort (CRQ) is a CD36-related receptor expressed exclusively on these macrophages. Genetic evidence showed that crq was essential for efficient phagocytosis of apoptotic corpses but was not required for the engulfment of bacteria. The expression of CRQ was regulated by the amount of apoptosis. These data define distinct pathways for the phagocytosis of corpses and bacteria in Drosophila.

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Year:  1999        PMID： 10373118     DOI： 10.1126/science.284.5422.1991

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  105 in total

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Review 2.  Phagocyte receptors for apoptotic cells: recognition, uptake, and consequences.

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4.  The Drosophila TRPP cation channel, PKD2 and Dmel/Ced-12 act in genetically distinct pathways during apoptotic cell clearance.

Authors:  Emeline Van Goethem; Elizabeth A Silva; Hui Xiao; Nathalie C Franc
Journal:  PLoS One       Date:  2012-02-08       Impact factor: 3.240

Review 5.  CD36: implications in cardiovascular disease.

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7.  Six-microns-under acts upstream of Draper in the glial phagocytosis of apoptotic neurons.

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Review 8.  Phagosome maturation: going through the acid test.

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9.  Integrin αPS3/βν-mediated phagocytosis of apoptotic cells and bacteria in Drosophila.

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Journal:  J Biol Chem       Date:  2013-02-20       Impact factor: 5.157

10.  A CD36-related transmembrane protein is coordinated with an intracellular lipid-binding protein in selective carotenoid transport for cocoon coloration.

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