BACKGROUND: Previous studies have shown an increased frequency of chromosomal abnormalities in lymphocytes from animals and humans with cysticercosis. Some reports have suggested an association between cancer and cysticercosis. The aim of this study was to investigate the possible association between neurocysticercosis and cancer. METHODS: We designed a mortality rate study from the autopsy files of the Department of Pathology at the General Hospital of Mexico. A total of 1,271 autopsy files were reviewed. All files in which a malignant neoplasia was found during autopsy were selected as cases. Autopsies in which no malignant disease was found were used as controls. The odds ratio was determined between the frequency of neurocysticercosis in patients with any malignant neoplasia and that of the controls. RESULTS: Neurocysticercosis was more frequent in cases with malignant hematological diseases (MHD) than in controls (p = 0.01). The odds ratio for this association was 3.54, with 95% confidence interval from 1.17-9.79. CONCLUSIONS: Most human cancers arise from the interaction of a multiplicity of factors, including xenobiotics and endogenous constituents. Therefore, while it will be difficult to demonstrate that neurocysticercosis is a causal agent of malignant hematological diseases (MHD), it should be considered as a potential risk factor for cancer induction in countries where cysticercosis remains a public health problem.
BACKGROUND: Previous studies have shown an increased frequency of chromosomal abnormalities in lymphocytes from animals and humans with cysticercosis. Some reports have suggested an association between cancer and cysticercosis. The aim of this study was to investigate the possible association between neurocysticercosis and cancer. METHODS: We designed a mortality rate study from the autopsy files of the Department of Pathology at the General Hospital of Mexico. A total of 1,271 autopsy files were reviewed. All files in which a malignant neoplasia was found during autopsy were selected as cases. Autopsies in which no malignant disease was found were used as controls. The odds ratio was determined between the frequency of neurocysticercosis in patients with any malignant neoplasia and that of the controls. RESULTS:Neurocysticercosis was more frequent in cases with malignant hematological diseases (MHD) than in controls (p = 0.01). The odds ratio for this association was 3.54, with 95% confidence interval from 1.17-9.79. CONCLUSIONS: Most humancancers arise from the interaction of a multiplicity of factors, including xenobiotics and endogenous constituents. Therefore, while it will be difficult to demonstrate that neurocysticercosis is a causal agent of malignant hematological diseases (MHD), it should be considered as a potential risk factor for cancer induction in countries where cysticercosis remains a public health problem.
Authors: J Francisco Salomão; Marcos V Pone; André R A da Silva; René D Leibinger; Antonio R Bellas; João Maurício S Campos; José Roberto P Garrido; Elide Vanazzi; Ana C M W de Barros; Sheila M Pone; Márcia B Boechat Journal: Childs Nerv Syst Date: 2005-03-19 Impact factor: 1.475
Authors: Patrick C Ndimubanzi; Hélène Carabin; Christine M Budke; Hai Nguyen; Ying-Jun Qian; Elizabeth Rainwater; Mary Dickey; Stephanie Reynolds; Julie A Stoner Journal: PLoS Negl Trop Dis Date: 2010-11-02
Authors: Hélène Carabin; Patrick Cyaga Ndimubanzi; Christine M Budke; Hai Nguyen; Yingjun Qian; Linda Demetry Cowan; Julie Ann Stoner; Elizabeth Rainwater; Mary Dickey Journal: PLoS Negl Trop Dis Date: 2011-05-24
Authors: Camila Lourencini Cavellani; Aline Cristina Souza da Silva; Grace Kelly Naves de Aquino Ribeiro; Lívia Ferreira Oliveira; Mara Lúcia Fonseca Ferraz; Vicente de Paula Antunes Teixeira Journal: ScientificWorldJournal Date: 2013-10-29