Protective activity of ethyl apovincaminate on ischaemic anoxia of the brain.

Effects of ethyl apovincaminate (RGH-4405, Cavinton), a new cerebral metabolic and vasodilatory agent, on cerebral regulatory functions under ischaemic anoxia were studied on immobilized cats by EEG. Cortical resistance time increased and recovery time decreased for a long period after i.v. administration of the compound. Results point to the possibility of further enhancement of cerebral regulatory processes by specific drug effects. It is assumed that tolerance or adaptation to hypoxia might be increased by RGH-4405 if spontaneous regulatory processes are impaired.