| Literature DB >> 10371028 |
F Heidempergher1, P Pevarello, A Pillan, V Pinciroli, A Della Torre, C Speciale, M Marconi, M Cini, S Toma, F Greco, M Varasi.
Abstract
A series of pyrrolo[3,2-c]quinoline derivatives were synthesised and evaluated as inhibitors of selected enzymes of the kynurenine pathway. 7-Chloro-3-methyl-1H-pyrrolo[3,2-c]quinoline-4-carboxylic acid (7a) was found to be a relatively potent and selective inhibitor of kynurenine-3-hydroxylase (KYN-3-OHase). A molecular modelling study showed a good superimposition of 7a with PNU-156561 and kynurenine the natural substrate of KYN-3-OHase.Entities:
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Year: 1999 PMID： 10371028 DOI： 10.1016/s0014-827x(99)00009-9
Source DB: PubMed Journal: Farmaco ISSN： 0014-827X