Literature DB >> 1036914

Spectral mapping, a technique for classifying biological activity profiles of chemical compounds.

P J Lewi.   

Abstract

A mathematical technique is described that separates potency from spectral information in biological activity spectra. The technique is a preliminary step in the classification of chemical compounds and in the structuring of pharmacological assays. The method is illustrated using previously reported results on 40 neuroleptics in 12 assays on rats. Principal component analysis and cluster analysis are shown to provide complementing information.

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Year:  1976        PMID： 1036914

Source DB:  PubMed          Journal:  Arzneimittelforschung        ISSN： 0004-4172


  11 in total

1.  Immunotyping of human immunodeficiency virus type 1 (HIV): an approach to immunologic classification of HIV.

Authors:  S Zolla-Pazner; M K Gorny; P N Nyambi; T C VanCott; A Nádas
Journal:  J Virol       Date:  1999-05       Impact factor: 5.103

2.  Biological spectra analysis: Linking biological activity profiles to molecular structure.

Authors:  Anton F Fliri; William T Loging; Peter F Thadeio; Robert A Volkmann
Journal:  Proc Natl Acad Sci U S A       Date:  2004-12-29       Impact factor: 11.205

3.  Study of the dynamics of neutralization escape mutants in a chimpanzee naturally infected with the simian immunodeficiency virus SIVcpz-ant.

Authors:  P N Nyambi; P Lewi; M Peeters; W Janssens; L Heyndrickx; K Fransen; K Andries; M Vanden Haesevelde; J Heeney; P Piot; G van der Groen
Journal:  J Virol       Date:  1997-03       Impact factor: 5.103

4.  Two groups of rhinoviruses revealed by a panel of antiviral compounds present sequence divergence and differential pathogenicity.

Authors:  K Andries; B Dewindt; J Snoeks; L Wouters; H Moereels; P J Lewi; P A Janssen
Journal:  J Virol       Date:  1990-03       Impact factor: 5.103

5.  Prediction of the Bobon clinical profile of neuroleptics from animal pharmacological data.

Authors:  J Kelder
Journal:  Psychopharmacology (Berl)       Date:  1982       Impact factor: 4.530

6.  On the classification of antidepressant drugs.

Authors:  P J Lewi; F C Colpaert
Journal:  Psychopharmacology (Berl)       Date:  1976-09-17       Impact factor: 4.530

7.  The novel anticonvulsant loreclezole (R 72063) does not produce diazepam-like anterograde amnesia in a passive avoidance test in rats.

Authors:  R B Raffa; J L Vaught; P E Setler
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-11       Impact factor: 3.000

8.  Immunoreactivity of intact virions of human immunodeficiency virus type 1 (HIV-1) reveals the existence of fewer HIV-1 immunotypes than genotypes.

Authors:  P N Nyambi; A Nádas; H A Mbah; S Burda; C Williams; M K Gorny; S Zolla-Pazner
Journal:  J Virol       Date:  2000-11       Impact factor: 5.103

9.  Multivariate analysis of human immunodeficiency virus type 1 neutralization data.

Authors:  P N Nyambi; J Nkengasong; P Lewi; K Andries; W Janssens; K Fransen; L Heyndrickx; P Piot; G van der Groen
Journal:  J Virol       Date:  1996-09       Impact factor: 5.103

10.  Development and evaluation of a multiplexed mass spectrometry based assay for measuring candidate peptide biomarkers in Alzheimer's Disease Neuroimaging Initiative (ADNI) CSF.

Authors:  Daniel S Spellman; Kristin R Wildsmith; Lee A Honigberg; Marianne Tuefferd; David Baker; Nandini Raghavan; Angus C Nairn; Pascal Croteau; Michael Schirm; Rene Allard; Julie Lamontagne; Daniel Chelsky; Steven Hoffmann; William Z Potter
Journal:  Proteomics Clin Appl       Date:  2015-04-24       Impact factor: 3.494
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