Literature DB >> 1036908

Binding of inorganic mercury by subcellllar fractions and proteins of rat kidneys.

E Komsta-Szumska, J Chmielnicka, J K Piotrowski.   

Abstract

Inorganic mercury, administered to rats in a single dose of 0.5 mg Hg/kg is accumulated in the kidneys mainly in the soluble (54%) and nuclear (30%) fractions, showing decreasing tendency with time. Mitochondrial and microsomal fractions, initially accumulating approx. 11 and 6% of total Hg, show a tendency to increase the absolute level of Hg for the first week after administration. In the soluble fraction low-molecular weight, metallothioneinlike proteins are mainly responsible for the accumulation of mercury, in other fractions proteins of higher molecular weight prevail.

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Year:  1976        PMID： 1036908     DOI： 10.1007/BF00353355

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  15 in total

1.  'GLUCOSE 6-PHOSPHATE-DEHYDROGENASE' ACTIVITY AND THIOL CONTENT OF THYMUS NUCLEI FROM CONTROL AND X-IRRADIATED RATS.

Authors:  H DEAKIN; M G ORD; L A STOCKEN
Journal:  Biochem J       Date:  1963-11       Impact factor: 3.857

2.  A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.

Authors:  K BURTON
Journal:  Biochem J       Date:  1956-02       Impact factor: 3.857

3.  Enzymic content of the mitochondria fraction.

Authors:  C DE DUVE; R GIANETTO; F APPELMANS; R WATTIAUX
Journal:  Nature       Date:  1953-12-19       Impact factor: 49.962

4.  Studies of nuclear acidic proteins. Evidence for their phosphorylation, tissue specificity, selective binding to deoxyribonucleic acid, and stimulation effects on transcription.

Authors:  C S Teng; C T Teng; V G Allfrey
Journal:  J Biol Chem       Date:  1971-06-10       Impact factor: 5.157

5.  Studies on metal-binding proteins of low molecular weight from renal tissue of rabbits exposed to cadmium or mercury.

Authors:  M Nordbery; B Trojanowska; G F Nordberg
Journal:  Environ Physiol Biochem       Date:  1974

6.  Quantitative studies on the flavins in the soluble fractions of heavy mitochondria of rat liver.

Authors:  D R Patek; W R Frisell
Journal:  Arch Biochem Biophys       Date:  1972-06       Impact factor: 4.013

7.  Binding of mercury in the rat kidney by metallothionein.

Authors:  J M Wiśniewska; B Trojanowska; J Piotrowski; M Jakubowski
Journal:  Toxicol Appl Pharmacol       Date:  1970-05       Impact factor: 4.219

8.  Thiol proteins in nuclei from rat liver and thymus.

Authors:  W H Marsh; M G Ord; L A Stocken
Journal:  Biochem J       Date:  1964-12       Impact factor: 3.857

9.  Elimination, tissue accumulation, and cellular incorporation of mercury in rats receiving an oral dose of 203Hg-labeled phenylmercuric acetate and mercuric acetate.

Authors:  R W Ellis; S C Fang
Journal:  Toxicol Appl Pharmacol       Date:  1967-07       Impact factor: 4.219

10.  Mercury binding in the kidney and liver of rats repeatedly exposed to mercuric chloride: induction of metallothionein by mercury and cadmium.

Authors:  J K Piotrowski; B Trojanowska; J M Wiśniewska-Knypl; W Bolanowska
Journal:  Toxicol Appl Pharmacol       Date:  1974-01       Impact factor: 4.219
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  2 in total

1.  Localization of mercury in the kidney during experimental acute tubular necrosis studied by the cytochemical Silver Amplification method.

Authors:  P Hultman; S Eneström
Journal:  Br J Exp Pathol       Date:  1986-08

2.  The influence of administered mass on the subcellular distribution and binding of mercury in rat liver and kidney.

Authors:  F Planas-Bohne; D M Taylor; R Walser
Journal:  Arch Toxicol       Date:  1985-02       Impact factor: 5.153
  2 in total

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