Literature DB >> 1036888

Therapeutic effects of some cholinolytics in organophosphate intoxications.

J Faff, G Borkowska, W Bak.   

Abstract

The therapeutic effects of pipethanate (sycotrol) and two newly synthetized cholinolytics, DPX-8 and ANC-51, were compared with atropine in mice poisoned by DDVP, fluostigmine, phospholine, and paraoxon. The antagonistic activotagonistic activity of tested drugs against acetylcholine-induced contraction of rat ileum and oxotremorine-induced salivation and tremor in the mouse was also studied. The anticholinergic activity of pipethanate, DPX-8, and ANC-51 was weaker than that of atropine. However,the therapeutic effect of pipethanate was higher than that of atropine in mice poisoned by the organophosphates. DPX-8 and ANC-51 afforded a better antidotal effect than atropine only in DDVP-poisoned mice.

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Year:  1976        PMID： 1036888     DOI： 10.1007/BF00351973

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  8 in total

1.  Affinity, intrinsic activity and drug interactions.

Authors:  E J ARIENS; J M VAN ROSSUM; A M SIMONIS
Journal:  Pharmacol Rev       Date:  1957-06       Impact factor: 25.468

2.  Synthetic substitutes for atropine.

Authors:  H R ING; G S DAWES; I WAJDA
Journal:  J Pharmacol Exp Ther       Date:  1945       Impact factor: 4.030

3.  USE OF MOVING AVERAGES AND INTERPOLATION TO ESTIMATE MEDIAN-EFFECTIVE DOSE: I. Fundamental Formulas, Estimation of Error, and Relation to Other Methods.

Authors:  W R Thompson
Journal:  Bacteriol Rev       Date:  1947-06

4.  pA, a new scale for the measurement of drug antagonism.

Authors:  H O SCHILD
Journal:  Br J Pharmacol Chemother       Date:  1947-09

5.  Effective doses of some cholinolytics in the treatment of anticholinesterase poisoning.

Authors:  R Jović; M Milosević
Journal:  Eur J Pharmacol       Date:  1970-09-01       Impact factor: 4.432

6.  The protective effects of some tertiary and quarternary antimuscarinic drugs and oxime in rats poisoned by lethal doses of methylethoxy-(2-dimethylamino ethylthio)-phosphine oxide.

Authors:  N Rosić; V Vojvodić; M Vojvodić
Journal:  Arh Hig Rada Toksikol       Date:  1974       Impact factor: 1.948

7.  Cholinolytics in the treatment of anticholinesterase poisoning. V. The effectiveness of Parpanit with oximes in the treatment of organophosphorus poisoning.

Authors:  I W Coleman; G E Patton; R A Bannard
Journal:  Can J Physiol Pharmacol       Date:  1968-01       Impact factor: 2.273

8.  The protective actions of some anticholinergic drugs in sarin poisoning.

Authors:  R W Brimblecombe; D M Green; J A Stratton; P B Thompson
Journal:  Br J Pharmacol       Date:  1970-08       Impact factor: 8.739
  8 in total

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