N S Whitworth1, E F Magann, J C Morrison. 1. Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, USA.
Abstract
OBJECTIVE: This study was undertaken to evaluate the correspondence in fetal lung development between diamniotic twins. STUDY DESIGN: Lecithin/sphingomyelin ratios were determined for amniotic fluid specimens collected from each sac in 58 diamniotic twin pregnancies. RESULTS: Overall, the lecithin/sphingomyelin ratios of twin A and twin B and those of the larger and smaller twins of each pair were closely correlated (r >/= 0.83, P <.001). When stratified by gestational age, however, the percentage disparity in lecithin/sphingomyelin ratios between members of twin pairs was significantly greater at </=32 weeks' gestation (25%) than at >32 weeks' gestation (15%, P =.027). An analysis of the lecithin/sphingomyelin ratios of twins with a large lecithin/sphingomyelin ratio disparity (>/=20%) suggested that this disparity was a result of 1 twin having a lecithin/sphingomyelin ratio that was advanced for gestational age with respect to that of the co-twin. Disparities in lecithin/sphingomyelin ratio were not significantly affected by fetal sex or by discordance in size between the twins. CONCLUSION: At relatively early stages of diamniotic twin gestation (</=32 weeks' gestation), lecithin/sphingomyelin ratios should be obtained for both amniotic sacs to ensure accurate assessment of fetal lung maturity in both twins.
OBJECTIVE: This study was undertaken to evaluate the correspondence in fetal lung development between diamniotic twins. STUDY DESIGN:Lecithin/sphingomyelin ratios were determined for amniotic fluid specimens collected from each sac in 58 diamniotic twin pregnancies. RESULTS: Overall, the lecithin/sphingomyelin ratios of twin A and twin B and those of the larger and smaller twins of each pair were closely correlated (r >/= 0.83, P <.001). When stratified by gestational age, however, the percentage disparity in lecithin/sphingomyelin ratios between members of twin pairs was significantly greater at </=32 weeks' gestation (25%) than at >32 weeks' gestation (15%, P =.027). An analysis of the lecithin/sphingomyelin ratios of twins with a large lecithin/sphingomyelin ratio disparity (>/=20%) suggested that this disparity was a result of 1 twin having a lecithin/sphingomyelin ratio that was advanced for gestational age with respect to that of the co-twin. Disparities in lecithin/sphingomyelin ratio were not significantly affected by fetal sex or by discordance in size between the twins. CONCLUSION: At relatively early stages of diamniotic twin gestation (</=32 weeks' gestation), lecithin/sphingomyelin ratios should be obtained for both amniotic sacs to ensure accurate assessment of fetal lung maturity in both twins.
Authors: Ana L Moreno-Espinosa; Ameth Hawkins-Villarreal; Xavier P Burgos-Artizzu; David Coronado-Gutierrez; Santiago Castelazo; Diana L Lip-Sosa; Javiera Fuenzalida; Dahiana M Gallo; Tatiana Peña-Ramirez; Paula Zuazagoitia; Miriam Muñoz; Mauro Parra-Cordero; Eduard Gratacòs; Montse Palacio Journal: Sci Rep Date: 2022-05-30 Impact factor: 4.996
Authors: Ana L Moreno-Espinosa; Ameth Hawkins-Villarreal; David Coronado-Gutierrez; Xavier P Burgos-Artizzu; Raigam J Martínez-Portilla; Tatiana Peña-Ramirez; Dahiana M Gallo; Stefan R Hansson; Eduard Gratacòs; Montse Palacio Journal: J Clin Med Date: 2022-08-20 Impact factor: 4.964