Literature DB >> 1036839

Inhibition of ADP-induced platelet aggregation by adenosine tetraphosphate.

M J Harrison, R Brossmer.   

Abstract

In contrast to previous reports, highly purified adenosine tetraphosphate (AP4) does not induce the aggregation of platelets but inhibits the aggregation and release reaction in platelet-rich plasma promoted by ADP. The inhibitory action of AP4 on the aggregation by ADP is compared with that of AMP and ATP. The data presented suggest a competitive manner of inhibition of the ADP-induced aggregation by AP4.

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Year:  1976        PMID： 1036839

Source DB:  PubMed          Journal:  Thromb Haemost        ISSN： 0340-6245            Impact factor:   5.249


  2 in total

1.  Role of platelets in aspirin-sensitive bronchoconstriction in the guinea-pig; interactions with salicylic acid.

Authors:  J Lefort; B B Vargaftig
Journal:  Br J Pharmacol       Date:  1978-05       Impact factor: 8.739

2.  Specific but noncompetitive inhibition by 2-alkylthio analogues of adenosine 5'-monophosphate and adenosine 5'-triphosphate of human platelet aggregation induced by adenosine 5'-diphosphate.

Authors:  N J Cusack; S M Hourani
Journal:  Br J Pharmacol       Date:  1982-02       Impact factor: 8.739
  2 in total

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