Literature DB >> 10366867

Molecular manipulations as tools for enhancing our understanding of 5-HT neurotransmission.

D L Murphy1, C Wichems, Q Li, A Heils.   

Abstract

A developing trend in exploring the sites at which drugs act is to use molecular rather than chemical agents to alter receptors, intracellular signalling mechanisms or gene expression. The 5-HT neurotransmission system is targeted by drugs useful in many behavioural disorders, including anxiety, depression, psychosis and eating disorders. It also regulates many physiological functions and provides some examples of the potential use of these new molecular approaches. This article reviews the progress made in the molecular manipulation of 5-HT receptors and discusses the potential of such tools for the treatment of diseases associated with the 5-HT transmission system.

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Year:  1999        PMID： 10366867     DOI： 10.1016/s0165-6147(99)01325-5

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN： 0165-6147            Impact factor:   14.819


  9 in total

1.  Reduction in the density and expression, but not G-protein coupling, of serotonin receptors (5-HT1A) in 5-HT transporter knock-out mice: gender and brain region differences.

Authors:  Q Li; C Wichems; A Heils; K P Lesch; D L Murphy
Journal:  J Neurosci       Date:  2000-11-01       Impact factor: 6.167

Review 2.  The serotonin1A receptor: a representative member of the serotonin receptor family.

Authors:  Thomas J Pucadyil; Shanti Kalipatnapu; Amitabha Chattopadhyay
Journal:  Cell Mol Neurobiol       Date:  2005-06       Impact factor: 5.046

3.  Impaired hypothalamic-pituitary-adrenal axis and its feedback regulation in serotonin transporter knockout mice.

Authors:  Xue Jiang; Jing Wang; Tian Luo; Qian Li
Journal:  Psychoneuroendocrinology       Date:  2008-11-02       Impact factor: 4.905

4.  Weight gain associated with clozapine, olanzapine and risperidone in children and adolescents.

Authors:  C Fleischhaker; P Heiser; K Hennighausen; B Herpertz-Dahlmann; K Holtkamp; C Mehler-Wex; R Rauh; H Remschmidt; E Schulz; A Warnke
Journal:  J Neural Transm (Vienna)       Date:  2006-11-17       Impact factor: 3.575

Review 5.  Cellular and molecular alterations in mice with deficient and reduced serotonin transporters.

Authors:  Qian Li
Journal:  Mol Neurobiol       Date:  2006-08       Impact factor: 5.590

6.  Serotonin 2B receptor is required for heart development.

Authors:  C G Nebigil; D S Choi; A Dierich; P Hickel; M Le Meur; N Messaddeq; J M Launay; L Maroteaux
Journal:  Proc Natl Acad Sci U S A       Date:  2000-08-15       Impact factor: 11.205

7.  Effects of repeated low-dose soman exposure on monoamine levels in different brain structures in mice.

Authors:  D Christin; S Daulon; S Delamanche; N Perrier; P Breton; L Taysse
Journal:  Neurochem Res       Date:  2007-11-10       Impact factor: 3.996

8.  Neuropeptide S selectively inhibits the release of 5-HT and noradrenaline from mouse frontal cortex nerve endings.

Authors:  L Raiteri; E Luccini; C Romei; S Salvadori; G Calò
Journal:  Br J Pharmacol       Date:  2009-04-03       Impact factor: 8.739

9.  Social defeat: impact on fear extinction and amygdala-prefrontal cortical theta synchrony in 5-HTT deficient mice.

Authors:  Venu Narayanan; Rebecca S Heiming; Friederike Jansen; Jörg Lesting; Norbert Sachser; Hans-Christian Pape; Thomas Seidenbecher
Journal:  PLoS One       Date:  2011-07-27       Impact factor: 3.240
  9 in total

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