Literature DB >> 10365645

A simple HPLC method for simultaneous determination of mycophenolic acid and mycophenolic acid glucuronide in plasma.

J O Svensson1, C Brattström, J Säwe.   

Abstract

A reversed-phase high-performance liquid chromatographic method for the simultaneous determination of mycophenolic acid and its metabolite, mycophenolic acid glucuronide, is presented herein. Sample purification is limited to protein precipitation with acetonitrile. The analytes were separated on a C18 column with a mobile phase containing 30% acetonitrile and a 40 mm phosphoric acid buffer at pH 2.1 and measured with UV-detection at 215 nm.

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Year:  1999        PMID: 10365645     DOI: 10.1097/00007691-199906000-00012

Source DB:  PubMed          Journal:  Ther Drug Monit        ISSN: 0163-4356            Impact factor:   3.681


  3 in total

1.  Population pharmacokinetics of mycophenolic acid during the first week after renal transplantation.

Authors:  Christine E Staatz; Stephen B Duffull; Bryce Kiberd; Albert D Fraser; Susan E Tett
Journal:  Eur J Clin Pharmacol       Date:  2005-07-28       Impact factor: 2.953

2.  Mycophenolate pharmacokinetics and pharmacodynamics in belatacept treated renal allograft recipients - a pilot study.

Authors:  Sara Bremer; Nils T Vethe; Helge Rootwelt; Pål F Jørgensen; Jean Stenstrøm; Hallvard Holdaas; Karsten Midtvedt; Stein Bergan
Journal:  J Transl Med       Date:  2009-07-27       Impact factor: 5.531

3.  Validated Simple HPLC-UV Method for Mycophenolic Acid (MPA) Monitoring in Human Plasma. Internal Standardization: Is It Necessary?

Authors:  Paweł K Kunicki; Aleksandra Wróbel
Journal:  Molecules       Date:  2021-11-29       Impact factor: 4.411

  3 in total

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