| Literature DB >> 10365166 |
A McGoldrick1, J P Lowings, D J Paton.
Abstract
Analyses of transmissible gastroenteritis virus (TGEV) and porcine respiratory coronavirus (PRCV) isolates have suggested that tropism and pathogenicity are influenced by the spike protein and ORF 3. In general, enteric viruses (TGEV) have been shown to contain intact spike and ORF 3 genes, whilst respiratory isolates (PRCV) have major deletions within both regions. Virulence has been correlated to a functional ORF 3. Here, sequence analysis of a recent isolate of virulent TGEV, revealed a variant with an intact spike gene, but a large deletion in ORF 3a. This suggests that ORF 3a is not essential for enteric virulence.Entities:
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Year: 1999 PMID： 10365166 PMCID： PMC7087079 DOI： 10.1007/s007050050541
Source DB: PubMed Journal: Arch Virol ISSN： 0304-8608 Impact factor: 2.574