| Literature DB >> 10363969 |
K Schorr1, M Li, U Bar-Peled, A Lewis, A Heredia, B Lewis, C M Knudson, S J Korsmeyer, R Jäger, H Weiher, P A Furth.
Abstract
The impact of gain of Bcl-2 function on mammary epithelial cell survival was compared with loss of Bax function during the two stages of mammary gland involution. Bcl-2 gain of function reduced apoptosis 50% during the first stage and increased cell survival 70% during the second stage. Complete loss of Bax reduced apoptosis by 20% during the first stage without second stage effect. Partial loss of Bax was ineffective but increased cell survival 2.4-fold when combined with Bcl-2 gain. Gain of Bcl-2 function is more potent than loss of Bax function in regulating mammary epithelial cell survival in vivo.Entities:
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Year: 1999 PMID： 10363969
Source DB: PubMed Journal: Cancer Res ISSN： 0008-5472 Impact factor: 12.701