INTRODUCTION AND OBJECTIVE: In order to elucidate the genetic and environmental components involved in the susceptibility to develop attention deficit hyperactivity disorder (ADHD), a complex segregation analysis on nuclear families (n = 53) ascertained from affected probands belonging to Medellín, in the Antioquian State, Colombia, was performed. METHODS AND RESULTS: Models of cohort effect (non-inheritance), multifactorial, recessive major gene, non-major gene component and non-transmission of major gene were rejected. Contrarily, dominant and codominant major gene models and non-multifactorial component could not be rejected. Thus, the better model fitting the data was that of the major gene (dominant/codominant). This major gene explains more than 99.99% of the ADHD phenotypic variance (value of heritability in the mixed model equal to 0.007%), which permit to assume a low aport of the environmental component to the phenotype ADHD. Gene frequency of the major gene was 3% in the general population of Antioquia and its penetrance was closed to 30%. CONCLUSION: Some cautions and aspects related to the bias of the interview and diagnosis of the parents are discussed.
INTRODUCTION AND OBJECTIVE: In order to elucidate the genetic and environmental components involved in the susceptibility to develop attention deficit hyperactivity disorder (ADHD), a complex segregation analysis on nuclear families (n = 53) ascertained from affected probands belonging to Medellín, in the Antioquian State, Colombia, was performed. METHODS AND RESULTS: Models of cohort effect (non-inheritance), multifactorial, recessive major gene, non-major gene component and non-transmission of major gene were rejected. Contrarily, dominant and codominant major gene models and non-multifactorial component could not be rejected. Thus, the better model fitting the data was that of the major gene (dominant/codominant). This major gene explains more than 99.99% of the ADHD phenotypic variance (value of heritability in the mixed model equal to 0.007%), which permit to assume a low aport of the environmental component to the phenotype ADHD. Gene frequency of the major gene was 3% in the general population of Antioquia and its penetrance was closed to 30%. CONCLUSION: Some cautions and aspects related to the bias of the interview and diagnosis of the parents are discussed.
Authors: Esther A Croes; Rachid El Galta; Jeanine J Houwing-Duistermaat; Robert F Ferdinand; Sandra López León; Tessa A M Rademaker; Marieke C J Dekker; Ben A Oostra; Frank Verhulst; Cornelia M Van Duijn Journal: Eur J Epidemiol Date: 2005 Impact factor: 8.082
Authors: Mauricio Arcos-Burgos; Ana C Londoño; David A Pineda; Francisco Lopera; Juan David Palacio; Andres Arbelaez; Maria T Acosta; Jorge I Vélez; Francisco Xavier Castellanos; Maximilian Muenke Journal: Atten Defic Hyperact Disord Date: 2012-07-20
Authors: Mauricio Arcos-Burgos; F Xavier Castellanos; David Pineda; Francisco Lopera; Juan David Palacio; Luis Guillermo Palacio; Judith L Rapoport; Kate Berg; Joan E Bailey-Wilson; Maximilian Muenke Journal: Am J Hum Genet Date: 2004-10-20 Impact factor: 11.025
Authors: David A Pineda; Luis Guillermo Palacio; Isabel C Puerta; Vilma Merchán; Clara P Arango; Astrid Yuleth Galvis; Mónica Gómez; Daniel Camilo Aguirre; Francisco Lopera; Mauricio Arcos-Burgos Journal: Eur Child Adolesc Psychiatry Date: 2007-08 Impact factor: 4.785