Literature DB >> 10360756

Synthesis and structure-activity relationship of novel glycylcycline derivatives leading to the discovery of GAR-936.

P E Sum1, P Petersen.   

Abstract

A number of new glycylcyclines were synthesized for structure-activity relationship study. Many of the derivatives exhibit potent, broad spectrum antibacterial activity against both tetracycline susceptible and resistant organisms. GAR-936 (TBG-MINO) shows better activity than the previously reported DMG-MINO and DMG-DMDOT.

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Year:  1999        PMID： 10360756     DOI： 10.1016/s0960-894x(99)00216-4

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  45 in total

1.  Activities of the glycylcycline tigecycline (GAR-936) against 1,924 recent European clinical bacterial isolates.

Authors:  D Milatovic; F-J Schmitz; J Verhoef; A C Fluit
Journal:  Antimicrob Agents Chemother       Date:  2003-01       Impact factor: 5.191

2.  Population pharmacokinetics of tigecycline in patients with complicated intra-abdominal or skin and skin structure infections.

Authors:  S A Van Wart; J S Owen; E A Ludwig; A K Meagher; J M Korth-Bradley; B B Cirincione
Journal:  Antimicrob Agents Chemother       Date:  2006-08-28       Impact factor: 5.191

3.  Non-stochastic and stochastic linear indices of the molecular pseudograph's atom-adjacency matrix: a novel approach for computational in silico screening and "rational" selection of new lead antibacterial agents.

Authors:  Yovani Marrero-Ponce; Ricardo Medina Marrero; Francisco Torrens; Yamile Martinez; Milagros García Bernal; Vicente Romero Zaldivar; Eduardo A Castro; Ricardo Grau Abalo
Journal:  J Mol Model       Date:  2005-11-04       Impact factor: 1.810

4.  Effect of medium age and supplementation with the biocatalytic oxygen-reducing reagent oxyrase on in vitro activities of tigecycline against recent clinical isolates.

Authors:  Peter J Petersen; Patricia A Bradford
Journal:  Antimicrob Agents Chemother       Date:  2005-09       Impact factor: 5.191

5.  Presence of tetracycline resistance determinants and susceptibility to tigecycline and minocycline.

Authors:  Ad C Fluit; Alice Florijn; Jan Verhoef; Dana Milatovic
Journal:  Antimicrob Agents Chemother       Date:  2005-04       Impact factor: 5.191

6.  Functional, biophysical, and structural bases for antibacterial activity of tigecycline.

Authors:  Matthew W Olson; Alexey Ruzin; Eric Feyfant; Thomas S Rush; John O'Connell; Patricia A Bradford
Journal:  Antimicrob Agents Chemother       Date:  2006-06       Impact factor: 5.191

7.  In vitro and in vivo activities of tigecycline (GAR-936), daptomycin, and comparative antimicrobial agents against glycopeptide-intermediate Staphylococcus aureus and other resistant gram-positive pathogens.

Authors:  Peter J Petersen; Patricia A Bradford; William J Weiss; Timothy M Murphy; P E Sum; Steven J Projan
Journal:  Antimicrob Agents Chemother       Date:  2002-08       Impact factor: 5.191

8.  The complex interplay of iron, biofilm formation, and mucoidy affecting antimicrobial resistance of Pseudomonas aeruginosa.

Authors:  Amanda G Oglesby-Sherrouse; Louise Djapgne; Angela T Nguyen; Adriana I Vasil; Michael L Vasil
Journal:  Pathog Dis       Date:  2014-02-10       Impact factor: 3.166

9.  Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575.

Authors:  Lauren B Pickens; Woncheol Kim; Peng Wang; Hui Zhou; Kenji Watanabe; Shuichi Gomi; Yi Tang
Journal:  J Am Chem Soc       Date:  2009-12-09       Impact factor: 15.419

Review 10.  Newer antibacterial drugs for a new century.

Authors:  Gina Devasahayam; William M Scheld; Paul S Hoffman
Journal:  Expert Opin Investig Drugs       Date:  2010-02       Impact factor: 6.206
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