| Literature DB >> 10360755 |
J J Duan1, L Chen, C B Xue, Z R Wasserman, K D Hardman, M B Covington, R R Copeland, E C Arner, C P Decicco.
Abstract
A novel series of 13- and 14-membered macrocyclic amines was developed by linking the P1 and P2' groups. The synthesis entails stereoselective Frater alkylation to install the anti-succinate configuration and macrocyclic amination via nucleophilic displacement. This strategy resulted in a new class of conformationally constrained inhibitors that are potent and selective for MMP-8 and 9 over MMP-1 and 3.Entities:
Mesh：
Substances：
Year: 1999 PMID： 10360755 DOI： 10.1016/s0960-894x(99)00215-2
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823