Literature DB >> 10360750

Uncarinic acids: phospholipase Cgamma1 inhibitors from hooks of Uncaria rhynchophylla.

J S Lee1, M Y Yang, H Yeo, J Kim, H S Lee, J S Ahn.   

Abstract

Bioactivity-guided fractionation of the CHCl3 extract from hooks of Uncaria rhynchophylla led to the isolation of two triterpene esters, namely uncarinic acids A (1) and B (2). Their structures were established by spectroscopic and chemical methods. These compounds inhibited phospholipase Cgamma1 with IC50 values of 35.66 and 44.55 microM, respectively.

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Year:  1999        PMID: 10360750     DOI: 10.1016/s0960-894x(99)00211-5

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  1 in total

1.  A new triterpene From Uncaria macrophylla and its antitumor activity.

Authors:  Guangli Sun; Xiaopo Zhang; Xudong Xu; Junshan Yang; Mingliang Zhong; Jingquan Yuan
Journal:  Molecules       Date:  2012-02-14       Impact factor: 4.411

  1 in total

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