| Literature DB >> 10360745 |
R Güller1, A Binggeli, V Breu, D Bur, W Fischli, G Hirth, C Jenny, M Kansy, F Montavon, M Müller, C Oefner, H Stadler, E Vieira, M Wilhelm, W Wostl, H P Märki.
Abstract
Piperidine renin inhibitors with heterocyclic core modifications or hydrophilic attachments show improved physical properties (lower lipophilicity, improved solubility). Tetrahydroquinoline derivative rac-30 with a molecular weight of 517 and a log D(pH 7.4) of 1.9 displays potent and long lasting blood pressure lowering effects after oral administration to sodium depleted conscious marmosets.Entities:
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Year: 1999 PMID： 10360745 DOI： 10.1016/s0960-894x(99)00196-1
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823