Literature DB >> 10360737

Methionyl adenylate analogues as inhibitors of methionyl-tRNA synthetase.

J Lee1, S U Kang, M K Kang, M W Chun, Y J Jo, J H Kwak, S Kim.   

Abstract

Four stable analogues of methionyl adenylate (3-6) were designed as inhibitors of methionyl-tRNA synthetase and synthesized from 2',3'-isopropylideneadenosine. They strongly inhibited aminoacylation activity of methionyl-tRNA synthetases isolated from Escherichia coli, Mycobacterium tuberculosis, Saccharomyces cerevisiae and human. Among the microorganisms tested, however, these chemicals showed the growth inhibition effect only on E. coli.

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Year:  1999        PMID： 10360737     DOI： 10.1016/s0960-894x(99)00206-1

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

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2.  Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.

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3.  Selective inhibition of biotin protein ligase from Staphylococcus aureus.

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4.  Dual-targeted hit identification using pharmacophore screening.

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Review 5.  Non-conventional sources of peptides presented by MHC class I.

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Journal:  Cell Mol Life Sci       Date:  2011-03-10       Impact factor: 9.261

6.  Novel hybrid virtual screening protocol based on molecular docking and structure-based pharmacophore for discovery of methionyl-tRNA synthetase inhibitors as antibacterial agents.

Authors:  Chi Liu; Gu He; Qinglin Jiang; Bo Han; Cheng Peng
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Review 7.  A Quick Guide to Small-Molecule Inhibitors of Eukaryotic Protein Synthesis.

Authors:  S E Dmitriev; D O Vladimirov; K A Lashkevich
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8.  A distinct translation initiation mechanism generates cryptic peptides for immune surveillance.

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  8 in total

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