Literature DB >> 10354702

The catalytic subunit of cAMP-dependent protein kinase: prototype for an extended network of communication.

C M Smith1, E Radzio-Andzelm, P Akamine, S S Taylor.   

Abstract

The protein kinase catalytic core in essence comprises an extended network of interactions that link distal parts of the molecule to the active site where they facilitate phosphoryl transfer from ATP to protein substrate. This review defines key sequence and structural elements, describes what is currently known about the molecular interactions, and how they are involved in catalysis.

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Year:  1999        PMID： 10354702     DOI： 10.1016/s0079-6107(98)00059-5

Source DB:  PubMed          Journal:  Prog Biophys Mol Biol        ISSN： 0079-6107            Impact factor:   3.667


  34 in total

1.  Amino acids determining enzyme-substrate specificity in prokaryotic and eukaryotic protein kinases.

Authors:  Lewyn Li; Eugene I Shakhnovich; Leonid A Mirny
Journal:  Proc Natl Acad Sci U S A       Date:  2003-04-04       Impact factor: 11.205

2.  Using substrate-binding variants of the cAMP-dependent protein kinase to identify novel targets and a kinase domain important for substrate interactions in Saccharomyces cerevisiae.

Authors:  Stephen J Deminoff; Susie C Howard; Arelis Hester; Sarah Warner; Paul K Herman
Journal:  Genetics       Date:  2006-06-04       Impact factor: 4.562

3.  Release of ADP from the catalytic subunit of protein kinase A: a molecular dynamics simulation study.

Authors:  Benzhuo Lu; Chung F Wong; J Andrew McCammon
Journal:  Protein Sci       Date:  2005-01       Impact factor: 6.725

4.  Conformational dependence of a protein kinase phosphate transfer reaction.

Authors:  Graeme Henkelman; Montiago X LaBute; Chang-Shung Tung; P W Fenimore; Benjamin H McMahon
Journal:  Proc Natl Acad Sci U S A       Date:  2005-10-14       Impact factor: 11.205

5.  Distal recognition sites in substrates are required for efficient phosphorylation by the cAMP-dependent protein kinase.

Authors:  Stephen J Deminoff; Vidhya Ramachandran; Paul K Herman
Journal:  Genetics       Date:  2009-04-13       Impact factor: 4.562

6.  Evolution of the genetic code by incorporation of amino acids that improved or changed protein function.

Authors:  Brian R Francis
Journal:  J Mol Evol       Date:  2013-06-07       Impact factor: 2.395

7.  The identification and analysis of phosphorylation sites on the Atg1 protein kinase.

Authors:  Yuh-Ying Yeh; Khyati H Shah; Chi-Chi Chou; He-Hsuan Hsiao; Kristie M Wrasman; Joseph S Stephan; Demetra Stamatakos; Kay-Hooi Khoo; Paul K Herman
Journal:  Autophagy       Date:  2011-07-01       Impact factor: 16.016

8.  A QM/MM study of the associative mechanism for the phosphorylation reaction catalyzed by protein kinase A and its D166A mutant.

Authors:  Ayax Pérez-Gallegos; Mireia Garcia-Viloca; Àngels González-Lafont; José M Lluch
Journal:  J Comput Aided Mol Des       Date:  2014-08-17       Impact factor: 3.686

9.  MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm.

Authors:  Jérôme Boudeau; Annette F Baas; Maria Deak; Nick A Morrice; Agnieszka Kieloch; Mike Schutkowski; Alan R Prescott; Hans C Clevers; Dario R Alessi
Journal:  EMBO J       Date:  2003-10-01       Impact factor: 11.598

10.  A transition path ensemble study reveals a linchpin role for Mg(2+) during rate-limiting ADP release from protein kinase A.

Authors:  Ilja V Khavrutskii; Barry Grant; Susan S Taylor; J Andrew McCammon
Journal:  Biochemistry       Date:  2009-12-08       Impact factor: 3.162
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