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Literature DB >> 10354616

The interactions of adenylate cyclases with P-site inhibitors.

C W Dessauer¹, J J Tesmer, S R Sprang, A G Gilman.

Abstract

Recent kinetic, binding and crystallographic studies using P-site inhibitors of mammalian adenylate bases provide new insights into the catalytic mechanism of these highly regulated enzymes. Here, Carmen Dessauer and colleagues discuss the conformational states of adenylate cyclase, the structural determinants of inhibitor binding and the potential uses of these inhibitors as pharmacological agents.

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Year: 1999 PMID： 10354616 DOI： 10.1016/s0165-6147(99)01310-3

Source DB: PubMed Journal: Trends Pharmacol Sci ISSN： 0165-6147 Impact factor: 14.819

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Cited

29 in total

1. Guanylyl cyclase is an ATP sensor coupling nitric oxide signaling to cell metabolism.

Authors: I Ruiz-Stewart; S R Tiyyagura; J E Lin; S Kazerounian; G M Pitari; S Schulz; E Martin; F Murad; S A Waldman
Journal: Proc Natl Acad Sci U S A Date: 2003-12-18 Impact factor: 11.205

Review 2. Molecular details of cAMP generation in mammalian cells: a tale of two systems.

Authors: Margarita Kamenetsky; Sabine Middelhaufe; Erin M Bank; Lonny R Levin; Jochen Buck; Clemens Steegborn
Journal: J Mol Biol Date: 2006-07-28 Impact factor: 5.469

3. Regulation of type V adenylate cyclase by Ric8a, a guanine nucleotide exchange factor.

Authors: Shyi-Chyi Wang; Hsing-Lin Lai; Yi-Ting Chiu; Ren Ou; Chuen-Lin Huang; Yijuang Chern
Journal: Biochem J Date: 2007-09-15 Impact factor: 3.857

Review 4. New insight into the functioning of nitric oxide-receptive guanylyl cyclase: physiological and pharmacological implications.

Authors: John Garthwaite
Journal: Mol Cell Biochem Date: 2009-12-11 Impact factor: 3.396

5. Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate.

Authors: Silke Kleinboelting; Ana Diaz; Sebastien Moniot; Joop van den Heuvel; Michael Weyand; Lonny R Levin; Jochen Buck; Clemens Steegborn
Journal: Proc Natl Acad Sci U S A Date: 2014-02-24 Impact factor: 11.205

The interactions of adenylate cyclases with P-site inhibitors.

1. Guanylyl cyclase is an ATP sensor coupling nitric oxide signaling to cell metabolism.

Review 2. Molecular details of cAMP generation in mammalian cells: a tale of two systems.

3. Regulation of type V adenylate cyclase by Ric8a, a guanine nucleotide exchange factor.

Review 4. New insight into the functioning of nitric oxide-receptive guanylyl cyclase: physiological and pharmacological implications.

5. Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate.

6. Effect of MANT-nucleotides on L-type calcium currents in murine cardiomyocytes.

7. A novel mechanism for adenylyl cyclase inhibition from the crystal structure of its complex with catechol estrogen.

8. A new site and mechanism of action for the widely used adenylate cyclase inhibitor SQ22,536.

Review 9. Inhibitors of membranous adenylyl cyclases.

10. Isoform selectivity of adenylyl cyclase inhibitors: characterization of known and novel compounds.