| Literature DB >> 10354552 |
P Brandtzaeg1, I N Farstad, G Haraldsen.
Abstract
According to the current paradigm of lymphocyte trafficking, primed B and T cells extravasate in the intestinal lamina propria chiefly by means of the mucosal homing receptor alpha4beta7, which interacts with the vascular addressin MAdCAM-1. However, as discussed here, this mechanism cannot explain the preferential homing of B cells with a high level of J-chain expression to mucosal effector sites outside the gut.Entities:
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Year: 1999 PMID： 10354552 DOI： 10.1016/s0167-5699(99)01468-1
Source DB: PubMed Journal: Immunol Today ISSN： 0167-5699