Literature DB >> 10354400

Synthesis and in vitro multidrug resistance modulating activity of a series of dihydrobenzopyrans and tetrahydroquinolines.

R Hiessböck1, C Wolf, E Richter, M Hitzler, P Chiba, M Kratzel, G Ecker.   

Abstract

A series of dihydrobenzopyrans and tetrahydroquinolines was synthesized and pharmacologically tested for their ability to inhibit P-glycoprotein mediated daunomycin efflux in multidrug resistant CCRF-CEM vcr1000 cells. Several compounds exhibit activities in the range of the reference compounds verapamil and propafenone. Preliminary structure-activity relationship studies propose the importance of high molar refractivity values of the compounds and the presence of an additional basic nitrogen atom.

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Year:  1999        PMID： 10354400     DOI： 10.1021/jm980517+

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  14 in total

1.  MCASE study of the multidrug resistance reversal activity of propafenone analogs.

Authors:  Gilles Klopman; Hao Zhu; Gerhard Ecker; Peter Chiba
Journal:  J Comput Aided Mol Des       Date:  2003 May-Jun       Impact factor: 3.686

2.  β-Hydroxy-tetrahydroquinolines from Quinolines Using Chloroborane: Synthesis of the Peptidomimetic FISLE-412.

Authors:  Ahmad S Altiti; Kai Fan Cheng; Mingzhu He; Yousef Al-Abed
Journal:  Chemistry       Date:  2017-07-26       Impact factor: 5.236

3.  Electron-induced (EI) mass fragmentation is directed by intra-molecular H-bonding in two isomeric benzodipyran systems.

Authors:  Cornelis J Van der Schyf; Stéphane Mabic
Journal:  Molecules       Date:  2004-09-30       Impact factor: 4.411

4.  A novel approach for predicting P-glycoprotein (ABCB1) inhibition using molecular interaction fields.

Authors:  Fabio Broccatelli; Emanuele Carosati; Annalisa Neri; Maria Frosini; Laura Goracci; Tudor I Oprea; Gabriele Cruciani
Journal:  J Med Chem       Date:  2011-02-22       Impact factor: 7.446

5.  CuCl2-catalyzed one-pot formation of tetrahydroquinolines from N-methyl-N-alkylanilines and vinyl ethers in the presence of t-butylhydroperoxide.

Authors:  Xianghua Yang; Chanjuan Xi; Yanfeng Jiang
Journal:  Molecules       Date:  2006-12-20       Impact factor: 4.411

6.  Prediction of promiscuous p-glycoprotein inhibition using a novel machine learning scheme.

Authors:  Max K Leong; Hong-Bin Chen; Yu-Hsuan Shih
Journal:  PLoS One       Date:  2012-03-16       Impact factor: 3.240

7.  HZ08 reverse P-glycoprotein mediated multidrug resistance in vitro and in vivo.

Authors:  Zheyi Hu; Zaigang Zhou; Yahui Hu; Jinhui Wu; Yunman Li; Wenlong Huang
Journal:  PLoS One       Date:  2015-02-17       Impact factor: 3.240

8.  2D- and 3D-QSAR studies of a series of benzopyranes and benzopyrano[3,4b][1,4]-oxazines as inhibitors of the multidrug transporter P-glycoprotein.

Authors:  Ishrat Jabeen; Penpun Wetwitayaklung; Peter Chiba; Manuel Pastor; Gerhard F Ecker
Journal:  J Comput Aided Mol Des       Date:  2013-02-12       Impact factor: 3.686

9.  Simvastatin-induced compartmentalisation of doxorubicin sharpens up nuclear topoisomerase II inhibition in human rhabdomyosarcoma cells.

Authors:  Martin Werner; Bihter Atil; Evelyn Sieczkowski; Peter Chiba; Martin Hohenegger
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2013-04-07       Impact factor: 3.000

10.  Crystal structure of 1-[(2S*,4R*)-6-fluoro-2-methyl-1,2,3,4-tetra-hydro-quinolin-4-yl]pyrrolidin-2-one.

Authors:  P S Pradeep; S Naveen; M N Kumara; K M Mahadevan; N K Lokanath
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2014-08-30
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