Literature DB >> 10353046

Analysis of illicit ecstasy tablets: implications for clinical management in the accident and emergency department.

K Sherlock1, K Wolff, A W Hay, M Conner.   

Abstract

OBJECTIVE: To examine the composition of illicitly manufactured "ecstasy" tablets sold on the UK drugs market.
METHODS: Analysis by gas chromatography of 25 illicit ecstasy tablets handed in under amnesty to Leeds Addiction Unit.
RESULTS: Illicitly manufactured ecstasy tablets contain a range of ingredients, of widely differing concentrations, and even tablets with the same brand name have variable concentrations of active ingredients. Concentrations of 3,4-methylenedioxymethamphetamine (MDMA) more popularly known as ecstasy, varied 70-fold between tablets. Nine tablets contained neither MDMA nor related analogues.
CONCLUSIONS: These results have implications for emergency workers attending to those who have become casualties of the drug ecstasy. Those claiming to have ingested ecstasy may actually have taken other agents that require different clinical management.

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Year:  1999        PMID: 10353046      PMCID: PMC1343333          DOI: 10.1136/emj.16.3.194

Source DB:  PubMed          Journal:  J Accid Emerg Med        ISSN: 1351-0622


  9 in total

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Authors:  M Lanz; R Brenneisen; W Thormann
Journal:  Electrophoresis       Date:  1997-06       Impact factor: 3.535

2.  Pathology of deaths associated with "ecstasy" and "eve" misuse.

Authors:  C M Milroy; J C Clark; A R Forrest
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3.  Ketamine as an induction agent in anaesthetics.

Authors:  J W Dundee; J W Knox; G W Black; J Moore; S K Pandit; J Bovill; R S Clarke; S H Love; J Elliott; D L Coppel
Journal:  Lancet       Date:  1970-06-27       Impact factor: 79.321

4.  Analysis of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolites in plasma and urine by HPLC-DAD and GC-MS.

Authors:  H J Helmlin; K Bracher; D Bourquin; D Vonlanthen; R Brenneisen
Journal:  J Anal Toxicol       Date:  1996-10       Impact factor: 3.367

5.  Drinking, smoking, and illicit drug use among 15 and 16 year olds in the United Kingdom.

Authors:  P M Miller; M Plant
Journal:  BMJ       Date:  1996-08-17

6.  Alcohol and drug use in UK university students.

Authors:  E Webb; C H Ashton; P Kelly; F Kamali
Journal:  Lancet       Date:  1996-10-05       Impact factor: 79.321

7.  Toxicity and deaths from 3,4-methylenedioxymethamphetamine ("ecstasy")

Authors:  J A Henry; K J Jeffreys; S Dawling
Journal:  Lancet       Date:  1992-08-15       Impact factor: 79.321

8.  Pharmacokinetics and analgesic effects of i.m. and oral ketamine.

Authors:  I S Grant; W S Nimmo; J A Clements
Journal:  Br J Anaesth       Date:  1981-08       Impact factor: 9.166

9.  Bioavailability, pharmacokinetics, and analgesic activity of ketamine in humans.

Authors:  J A Clements; W S Nimmo; I S Grant
Journal:  J Pharm Sci       Date:  1982-05       Impact factor: 3.534

  9 in total
  11 in total

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Authors:  J D Ramsey; M A Butcher; M F Murphy; T Lee; A Johnston; D W Holt
Journal:  BMJ       Date:  2001-09-15

2.  MDMA effects consistent across laboratories.

Authors:  Matthew G Kirkpatrick; Matthew J Baggott; John E Mendelson; Gantt P Galloway; Matthias E Liechti; Cédric M Hysek; Harriet de Wit
Journal:  Psychopharmacology (Berl)       Date:  2014-03-15       Impact factor: 4.530

Review 3.  Clinical applications of hallucinogens: A review.

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Review 4.  The effects of ecstasy on neurotransmitter systems: a review on the findings of molecular imaging studies.

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Journal:  Psychopharmacology (Berl)       Date:  2016-08-28       Impact factor: 4.530

5.  Raves: a review of the culture, the drugs and the prevention of harm.

Authors:  E Weir
Journal:  CMAJ       Date:  2000-06-27       Impact factor: 8.262

Review 6.  The pharmacology and toxicology of "ecstasy" (MDMA) and related drugs.

Authors:  H Kalant
Journal:  CMAJ       Date:  2001-10-02       Impact factor: 8.262

7.  Is ecstasy MDMA? A review of the proportion of ecstasy tablets containing MDMA, their dosage levels, and the changing perceptions of purity.

Authors:  A C Parrott
Journal:  Psychopharmacology (Berl)       Date:  2004-03-09       Impact factor: 4.530

8.  What's in a label? Ecstasy sellers' perceptions of pill brands.

Authors:  Micheline Duterte; Camille Jacinto; Paloma Sales; Sheigla Murphy
Journal:  J Psychoactive Drugs       Date:  2009-03

9.  Effects of MDMA on olfactory memory and reversal learning in rats.

Authors:  Andrew Hawkey; L Brooke April; Mark Galizio
Journal:  Neurobiol Learn Mem       Date:  2014-07-10       Impact factor: 2.877

10.  Ecstasy-induced recurrent toxic hepatitis in a young adult.

Authors:  Ozlem Guneysel; Ozge Ecmel Onur; Haldun Akoglu; Arzu Denizbasi
Journal:  Curr Ther Res Clin Exp       Date:  2008-06
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