Literature DB >> 1035159

Isolated perfused rabbit lung: a critical appraisal.

R W Niemeier.   

Abstract

The isolated perfused lung (IPL), when compared to available in vitro and in vivo pulmonary systems, is a preparation that fulfills a majority of the ideal criteria for studying metabolism, binding and/or physiological response to xenobiotics. The IPL is an exceptionally useful method when there is a need for concurrent administration of multiple agents in different physical forms. Various details such as physiological and biochemical parameters and the construction of a small animal tracheal valve system are discussed.

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Year:  1976        PMID： 1035159      PMCID： PMC1475234          DOI： 10.1289/ehp.761667

Source DB:  PubMed          Journal:  Environ Health Perspect        ISSN： 0091-6765            Impact factor:   9.031


  11 in total

1.  An isolated perfused lung preparation for metabolic studies.

Authors:  R W Niemeier; E Bingham
Journal:  Life Sci II       Date:  1972-08-22

2.  K-region epoxides of polycyclic hydrocarbons: formation and further metabolism by rat-lung preparations.

Authors:  P L Grover
Journal:  Biochem Pharmacol       Date:  1974-01-15       Impact factor: 5.858

3.  Metabolism of polycyclic hydrocarbons by rat-lung preparations.

Authors:  P L Grover; A Hewer; P Sims
Journal:  Biochem Pharmacol       Date:  1974-01-15       Impact factor: 5.858

4.  The distribution and fate of 14C-cloforex in the lung of the rat.

Authors:  A Ryrfeldt; C H Ramsay; L E Appelgren
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1973

5.  Binding of chemical carcinogens in the lung.

Authors:  D O Toft; T C Spelsberg
Journal:  J Natl Cancer Inst       Date:  1974-04       Impact factor: 13.506

6.  Demethylation of nortriptyline by the dog lung.

Authors:  E Whitnack; D R Knapp; J C Holmes; N O Fowler; T E Gaffney
Journal:  J Pharmacol Exp Ther       Date:  1972-05       Impact factor: 4.030

7.  A lung perfusion preparation for the study of drug metabolism.

Authors:  P M Rosenbloom; A D Bass
Journal:  J Appl Physiol       Date:  1970-07       Impact factor: 3.531

8.  Comparison of microsomal drug hydroxylation in lung and liver of various species.

Authors:  W W Oppelt; M Zange; W E Ross; H Remmer
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1970-01

9.  Xenobiotic accumulation and metabolism by isolated perfused rabbit lungs.

Authors:  T C Orton; M W Anderson; R D Pickett; T E Eling; J R Fouts
Journal:  J Pharmacol Exp Ther       Date:  1973-09       Impact factor: 4.030

10.  Some studies and comments on hepatic and extrahepatic microsomal toxication-detoxication systems. A limited discussion of some of the heterogeneities of these systems and of their responses to stimulation of enzyme "induction".

Authors:  J R Fouts
Journal:  Environ Health Perspect       Date:  1972-10       Impact factor: 9.031
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  1 in total

Review 1.  The isolated perfused lung.

Authors:  R W Niemeier
Journal:  Environ Health Perspect       Date:  1984-06       Impact factor: 9.031
  1 in total

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