| Literature DB >> 10350603 |
J R Batalha1, E T Guimarães, D J Lobo, A J Lichtenfels, T Deur, H A Carvalho, E S Alves, M Domingos, G S Rodrigues, P H Saldiva.
Abstract
This study was designed to determine the clastogenicity of particulate matter (aerodynamic diameter smaller than 10 microm) in the urban polluted air in the city of São Paulo. The Tradescantia-micronucleus (Trad-MCN) assay was used throughout this study to evaluate the clastogenicity of the extracts of the particulate matter. Tradescantia pallida (Rose) Hunt. cv. purpurea, an indigenous cultivar, was used in the Trad-MCN assay. The efficacy of this plant material for the Trad-MCN assay was validated with dose-response studies using formaldehyde and beta radiation. Dose-response curves were established with these known mutagens. The extracts of the PM10 particles at concentrations between 5 and 50 ppm induced a dose-related increase in MCN frequencies. The results indicate that T. pallida is equally sensitive to mutagens as the standard Tradescantia clone 4430 or 03 and the particulate matter in the urban air are clastogenic to the chromosomes of this plant. Inhalation of these particles by urban dwellers may affect their health by inducing similar genetic damage. Copyright 1999 Elsevier Science B.V.Entities:
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Year: 1999 PMID： 10350603 DOI： 10.1016/s0027-5107(99)00073-1
Source DB: PubMed Journal: Mutat Res ISSN： 0027-5107 Impact factor: 2.433