Literature DB >> 10350193

The interaction of sarin and soman with plasma proteins: the identification of a novel phosphonylation site.

R M Black1, J M Harrison, R W Read.   

Abstract

Incubation of both sarin and soman with human plasma has shown that binding occurs to a tyrosine residue. Similar binding occurs when sarin and soman are incubated with human serum albumin. This binding may provide an important biological marker, which retains full structural information concerning the identity of the agent, in cases of allegations of chemical warfare use.

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Year:  1999        PMID： 10350193     DOI： 10.1007/s002040050596

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  18 in total

Review 1.  Protein adducts as biomarkers of exposure to organophosphorus compounds.

Authors:  Judit Marsillach; Lucio G Costa; Clement E Furlong
Journal:  Toxicology       Date:  2012-12-20       Impact factor: 4.221

Review 2.  Positron emission tomography studies of organophosphate chemical threats and oxime countermeasures.

Authors:  Charles M Thompson; John M Gerdes; Henry F VanBrocklin
Journal:  Neurobiol Dis       Date:  2019-04-22       Impact factor: 5.996

Review 3.  Review of tyrosine and lysine as new motifs for organophosphate binding to proteins that have no active site serine.

Authors:  Oksana Lockridge; Lawrence M Schopfer
Journal:  Chem Biol Interact       Date:  2010-03-06       Impact factor: 5.192

4.  Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry assay for organophosphorus toxicants bound to human albumin at Tyr411.

Authors:  Bin Li; Lawrence M Schopfer; Steven H Hinrichs; Patrick Masson; Oksana Lockridge
Journal:  Anal Biochem       Date:  2006-12-04       Impact factor: 3.365

Review 5.  Identification and characterization of biomarkers of organophosphorus exposures in humans.

Authors:  Jerry H Kim; Richard C Stevens; Michael J MacCoss; David R Goodlett; Alex Scherl; Rebecca J Richter; Stephanie M Suzuki; Clement E Furlong
Journal:  Adv Exp Med Biol       Date:  2010       Impact factor: 2.622

6.  Mass spectral characterization of organophosphate-labeled, tyrosine-containing peptides: characteristic mass fragments and a new binding motif for organophosphates.

Authors:  Lawrence M Schopfer; Hasmik Grigoryan; Bin Li; Florian Nachon; Patrick Masson; Oksana Lockridge
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2009-07-24       Impact factor: 3.205

7.  Covalent binding of the organophosphorus agent FP-biotin to tyrosine in eight proteins that have no active site serine.

Authors:  Hasmik Grigoryan; Bin Li; Erica K Anderson; Weihua Xue; Florian Nachon; Oksana Lockridge; Lawrence M Schopfer
Journal:  Chem Biol Interact       Date:  2009-04-02       Impact factor: 5.192

8.  Nanoparticle-based electrochemical immunosensor for the detection of phosphorylated acetylcholinesterase: an exposure biomarker of organophosphate pesticides and nerve agents.

Authors:  Guodong Liu; Jun Wang; Richard Barry; Catherine Petersen; Charles Timchalk; Paul L Gassman; Yuehe Lin
Journal:  Chemistry       Date:  2008       Impact factor: 5.236

Review 9.  Nanotechnology-based electrochemical sensors for biomonitoring chemical exposures.

Authors:  Richard C Barry; Yuehe Lin; Jun Wang; Guodong Liu; Charles A Timchalk
Journal:  J Expo Sci Environ Epidemiol       Date:  2008-11-19       Impact factor: 5.563

10.  Simultaneous measurement of tabun, sarin, soman, cyclosarin, VR, VX, and VM adducts to tyrosine in blood products by isotope dilution UHPLC-MS/MS.

Authors:  Brian S Crow; Brooke G Pantazides; Jennifer Quiñones-González; Joshua W Garton; Melissa D Carter; Jonas W Perez; Caroline M Watson; Dennis J Tomcik; Michael D Crenshaw; Bobby N Brewer; James R Riches; Sarah J Stubbs; Robert W Read; Ronald A Evans; Jerry D Thomas; Thomas A Blake; Rudolph C Johnson
Journal:  Anal Chem       Date:  2014-10-06       Impact factor: 6.986
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