PURPOSE: The purpose of this study was to investigate, using MRI, the potential morphologic effects of hormonal replacement therapy (HRT) on breast tissue in post-menopausal women. METHOD: Five subjects were enrolled who were treated subsequently with both estrogen (2 mg/day) and a combination of estrogen (2 mg/day) and progestagen (1 mg/day). T1-weighted (TR 11 ms, TE 4.65 ms, flip angle 35 degrees, two excitations) 3D MR scans were acquired on a 1.5 T whole-body scanner before therapy and after each regimen. With use of a segmentation algorithm and histogram evaluation, parenchymal tissue/fat ratios were calculated over targeted volumes and changes were assessed. RESULTS: An increase in these ratios was observed in two subjects after receiving the combined therapy, indicating a change in parenchymal pattern, whereas no obvious changes were detected in any of the subjects during the estrogen-based therapy. CONCLUSION: MRI is able to detect and quantitate changes in breast parenchyma during HRT.
PURPOSE: The purpose of this study was to investigate, using MRI, the potential morphologic effects of hormonal replacement therapy (HRT) on breast tissue in post-menopausal women. METHOD: Five subjects were enrolled who were treated subsequently with both estrogen (2 mg/day) and a combination of estrogen (2 mg/day) and progestagen (1 mg/day). T1-weighted (TR 11 ms, TE 4.65 ms, flip angle 35 degrees, two excitations) 3D MR scans were acquired on a 1.5 T whole-body scanner before therapy and after each regimen. With use of a segmentation algorithm and histogram evaluation, parenchymal tissue/fat ratios were calculated over targeted volumes and changes were assessed. RESULTS: An increase in these ratios was observed in two subjects after receiving the combined therapy, indicating a change in parenchymal pattern, whereas no obvious changes were detected in any of the subjects during the estrogen-based therapy. CONCLUSION: MRI is able to detect and quantitate changes in breast parenchyma during HRT.
Authors: Brian N Dontchos; Habib Rahbar; Savannah C Partridge; Larissa A Korde; Diana L Lam; John R Scheel; Sue Peacock; Constance D Lehman Journal: Radiology Date: 2015-05-12 Impact factor: 11.105
Authors: Stefan O R Pfleiderer; Steffen Sachse; Dieter Sauner; Christiane Marx; Ansgar Malich; Susanne Wurdinger; Werner A Kaiser Journal: Breast Cancer Res Date: 2004-03-16 Impact factor: 6.466