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Literature DB >> 10348371

Inhibitory effects of indomethacin on interleukin-1 and nitric oxide production in rat microglia in vitro.

Abstract

Indomethacin, as a nonsteroidal antiinflammatory drug, is reported to be effective in some degree in the prevention and treatment of Alzheimer's disease (AD). Effects of indomethacin on proinflammatory cytokines interleukin-1 (IL-1), tumor necrosis factor alpha and nitric oxide (NO) on rat microglia in vitro were investigated. The biological activities of IL-1 were assayed by thymocyte proliferation assay and the activities of TNG-alpha, by L929 cytotoxicity assay. NO concentration was represented by nitrite and determined by Griess reaction. Indomethacin inhibited IL-1 and NO production by rat microglia stimulated at the concentration of 0.1-10 micromol/l. However, it did not show any inhibitory effect on TNF-alpha production by resting and LPS-stimulated rat microglia. The results suggest that the mechanism by which indomethacin might be beneficial in treatment of AD might be due to the inhibition IL-1 and NO production from microglia.

Entities: Chemical Disease Gene Species

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Year: 1999 PMID： 10348371 DOI： 10.1016/s0192-0561(98)00084-8

Source DB: PubMed Journal: Int J Immunopharmacol ISSN： 0192-0561

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Cited

14 in total

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Inhibitory effects of indomethacin on interleukin-1 and nitric oxide production in rat microglia in vitro.

1. In vivo imaging of activated microglia in a mouse model of focal cerebral ischemia by two-photon microscopy.

2. A potential nitrergic mechanism of action for indomethacin, but not of other COX inhibitors: relevance to indomethacin-sensitive headaches.

3. Urinary nitrite excretion and urinary variables in patients with primary nocturnal frequency of micturition: effects of indomethacin suppositories.

Review 4. Role of the immune system in the pathogenesis, prevention and treatment of Alzheimer's disease.

Review 5. Mechanisms of non-opioid analgesics beyond cyclooxygenase enzyme inhibition.

Review 6. Mechanism of action of indomethacin in indomethacin-responsive headaches.

Review 7. Indomethacin-responsive headache syndromes.

Review 8. Indomethacin for the treatment of Alzheimer's disease patients.

9. The role of beta-amyloid protein in synaptic function: implications for Alzheimer's disease therapy.

10. Reduction of nuclear peroxisome proliferator-activated receptor gamma expression in methamphetamine-induced neurotoxicity and neuroprotective effects of ibuprofen.