Literature DB >> 10348049

Chemical modification of antibiotic eremomycin at the asparagine side chain.

E N Olsufyeva1, T F Berdnikova, O V Miroshnikova, M I Reznikova, M N Preobrazhenskaya.   

Abstract

AA3-Carboxyeremomycin 2, obtained by selective hydrolysis of antibiotic eremomycin was used as a starting compound for the eremomycin chemical modifications at the asparagine side chain to be transformed into eremomycin AA3, AA7 bis-amides (3a-c). Bis-benzylamide 3b displayed an activity (8 microg/ml) against an E. faecium VanA strain.

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Year:  1999        PMID: 10348049     DOI: 10.7164/antibiotics.52.319

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN: 0021-8820            Impact factor:   2.649


  5 in total

1.  The Carboxyl Terminus of Eremomycin Facilitates Binding to the Non-d-Ala-d-Ala Segment of the Peptidoglycan Pentapeptide Stem.

Authors:  James Chang; Hongyu Zhou; Maria Preobrazhenskaya; Peng Tao; Sung Joon Kim
Journal:  Biochemistry       Date:  2016-06-07       Impact factor: 3.162

Review 2.  Biological, chemical, and biochemical strategies for modifying glycopeptide antibiotics.

Authors:  Edward Marschall; Max J Cryle; Julien Tailhades
Journal:  J Biol Chem       Date:  2019-10-31       Impact factor: 5.157

3.  Eremomycin pyrrolidide: a novel semisynthetic glycopeptide with improved chemotherapeutic properties.

Authors:  Evgenia N Olsufyeva; Andrey E Shchekotikhin; Elena N Bychkova; Eleonora R Pereverzeva; Ivan D Treshalin; Elena P Mirchink; Elena B Isakova; Mikhail G Chernobrovkin; Roman S Kozlov; Andrey V Dekhnich; Maria N Preobrazhenskaya
Journal:  Drug Des Devel Ther       Date:  2018-09-10       Impact factor: 4.162

4.  Inhibition of feline (FIPV) and human (SARS) coronavirus by semisynthetic derivatives of glycopeptide antibiotics.

Authors:  Jan Balzarini; Els Keyaerts; Leen Vijgen; Herman Egberink; Erik De Clercq; Marc Van Ranst; Svetlana S Printsevskaya; Eugenia N Olsufyeva; Svetlana E Solovieva; Maria N Preobrazhenskaya
Journal:  Antiviral Res       Date:  2006-04-06       Impact factor: 5.970

5.  Molecular Dynamics Simulation of Atomic Interactions in the Vancomycin Binding Site.

Authors:  Olatunde P Olademehin; Sung Joon Kim; Kevin L Shuford
Journal:  ACS Omega       Date:  2020-12-22
  5 in total

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