Literature DB >> 10348043

Lactonamycin, a new antimicrobial antibiotic produced by Streptomyces rishiriensis MJ773-88K4. II. Structure determination.

N Matsumoto1, T Tsuchida, H Nakamura, R Sawa, Y Takahashi, H Naganawa, H Iinuma, T Sawa, T Takeuchi, M Shiro.   

Abstract

The absolute structure of a new antibiotic lactonamycin is described. The NMR studies deduced one of four possible structures for the aglycon attached by a rhodinose through glycosidic bond. The stereochemistry of the sugar obtained by an acid hydrolysis was determined to be L-form by measuring optical rotation. The stereochemistry of the aglycon was determined by X-ray crystallographic analysis.

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Year:  1999        PMID: 10348043     DOI: 10.7164/antibiotics.52.276

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN: 0021-8820            Impact factor:   2.649


  4 in total

1.  PM100117 and PM100118, new antitumor macrolides produced by a marine Streptomyces caniferus GUA-06-05-006A.

Authors:  Marta Pérez; Carmen Schleissner; Rogelio Fernández; Pilar Rodríguez; Fernando Reyes; Paz Zuñiga; Fernando de la Calle; Carmen Cuevas
Journal:  J Antibiot (Tokyo)       Date:  2015-12-09       Impact factor: 2.649

Review 2.  A comprehensive review of glycosylated bacterial natural products.

Authors:  Sherif I Elshahawi; Khaled A Shaaban; Madan K Kharel; Jon S Thorson
Journal:  Chem Soc Rev       Date:  2015-11-07       Impact factor: 54.564

3.  Biosynthetic investigations of lactonamycin and lactonamycin z: cloning of the biosynthetic gene clusters and discovery of an unusual starter unit.

Authors:  Xiujun Zhang; Lawrence B Alemany; Hans-Peter Fiedler; Michael Goodfellow; Ronald J Parry
Journal:  Antimicrob Agents Chemother       Date:  2007-12-10       Impact factor: 5.191

4.  Asymmetric synthesis of isochromanone derivatives via trapping carboxylic oxonium ylides and aldol cascade.

Authors:  Jiawen Lang; Siyuan Wang; Changli He; Xiaohua Liu; Xiaoming Feng
Journal:  Chem Sci       Date:  2021-12-27       Impact factor: 9.825

  4 in total

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