Literature DB >> 10347222

Cloning, tissue distribution, genomic organization, and functional characterization of NBC3, a new member of the sodium bicarbonate cotransporter family.

A Pushkin1, N Abuladze, I Lee, D Newman, J Hwang, I Kurtz.   

Abstract

Previous functional studies have demonstrated that muscle intracellular pH regulation is mediated by sodium-coupled bicarbonate transport, Na+/H+ exchange, and Cl-/bicarbonate exchange. We report the cloning, sequence analysis, tissue distribution, genomic organization, and functional analysis of a new member of the sodium bicarbonate cotransporter (NBC) family, NBC3, from human skeletal muscle. mNBC3 encodes a 1214-residue polypeptide with 12 putative membrane-spanning domains. The approximately 7.8-kilobase transcript is expressed uniquely in skeletal muscle and heart. The NBC3 gene (SLC4A7) spans approximately 80 kb and is composed of 25 coding exons and 24 introns that are flanked by typical splice donor and acceptor sequences. Expression of mNBC3 cRNA in Xenopus laevis oocytes demonstrated that the protein encodes a novel stilbene-insensitive 5-(N-ethyl-N-isopropyl)-amiloride-inhibitable sodium bicarbonate cotransporter.

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Year:  1999        PMID： 10347222     DOI： 10.1074/jbc.274.23.16569

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  55 in total

Review 1.  Why should a clinician care about the molecular biology of transport?

Authors:  A J Janecki
Journal:  Curr Gastroenterol Rep       Date:  2000-10

Review 2.  Molecular mechanisms of electrogenic sodium bicarbonate cotransport: structural and equilibrium thermodynamic considerations.

Authors:  I Kurtz; D Petrasek; S Tatishchev
Journal:  J Membr Biol       Date:  2004-01-15       Impact factor: 1.843

Review 3.  Molecular mechanism of pancreatic and salivary gland fluid and HCO3 secretion.

Authors:  Min Goo Lee; Ehud Ohana; Hyun Woo Park; Dongki Yang; Shmuel Muallem
Journal:  Physiol Rev       Date:  2012-01       Impact factor: 37.312

4.  A biophysical model for integration of electrical, osmotic, and pH regulation in the human bronchial epithelium.

Authors:  Cibele V Falkenberg; Eric Jakobsson
Journal:  Biophys J       Date:  2010-04-21       Impact factor: 4.033

5.  The electrogenic Na+/HCO3- cotransport modulates resting membrane potential and action potential duration in cat ventricular myocytes.

Authors:  María C Villa-Abrille; Martín G Vila Petroff; Ernesto A Aiello
Journal:  J Physiol       Date:  2006-11-30       Impact factor: 5.182

Review 6.  Ion channels and ion transporters of the transverse tubular system of skeletal muscle.

Authors:  Karin Jurkat-Rott; Michael Fauler; Frank Lehmann-Horn
Journal:  J Muscle Res Cell Motil       Date:  2006-08-24       Impact factor: 2.698

7.  The electrogenicity of the rat sodium-bicarbonate cotransporter NBCe1 requires interactions among transmembrane segments of the transporter.

Authors:  Inyeong Choi; Han Soo Yang; Walter F Boron
Journal:  J Physiol       Date:  2006-10-12       Impact factor: 5.182

8.  Splice cassette II of Na+,HCO3(-) cotransporter NBCn1 (slc4a7) interacts with calcineurin A: implications for transporter activity and intracellular pH control during rat artery contractions.

Authors:  Andreas A Danielsen; Mark D Parker; Soojung Lee; Walter F Boron; Christian Aalkjaer; Ebbe Boedtkjer
Journal:  J Biol Chem       Date:  2013-02-04       Impact factor: 5.157

9.  S0859, an N-cyanosulphonamide inhibitor of sodium-bicarbonate cotransport in the heart.

Authors:  F F-T Ch'en; F C Villafuerte; P Swietach; P M Cobden; R D Vaughan-Jones
Journal:  Br J Pharmacol       Date:  2008-01-21       Impact factor: 8.739

Review 10.  Modular structure of sodium-coupled bicarbonate transporters.

Authors:  Walter F Boron; Liming Chen; Mark D Parker
Journal:  J Exp Biol       Date:  2009-06       Impact factor: 3.312
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