| Literature DB >> 10346964 |
P Chatterjee1, J M Pezzuto, S A Kouzi.
Abstract
Microbial transformation of the antimelanoma agent betulinic acid (1) was studied. Preparative scale biotransformation with resting-cell suspensions of Cunninghamella species NRRL 5695 resulted in the production of a fungal metabolite of 1, which has been characterized as 28-O-beta-D-glucopyranosyl 3beta-hydroxy-lup-20(29)-en-28-oate (2) based on spectral and enzymic data. The in vitro cytotoxicity assay of metabolite 2 revealed no activity against several human melanoma cell lines.Entities:
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Year: 1999 PMID： 10346964 DOI： 10.1021/np980432b
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050