| Literature DB >> 10344601 |
E J Talavera1, J L Arcaya, D Giraldoth, J Suárez, E Bonilla.
Abstract
In the present study, we have evaluated whether melatonin (MEL) modulates Mn-induced decrease in spontaneous motor activity (SMA) and lipid peroxidation, estimated as malondialdehyde (MDA) formation, in several brain regions. In mice treated with manganese a decrease in SMA after 2 weeks of treatment was observed. In the group treated with Mn+MEL a significant greater reduction in SMA was detected at 4 weeks. MDA levels were reduced in both MEL and Mn treated mice. In the animals treated with MEL + Mn a higher reduction in MDA levels was observed. These results suggest that MEL modulates the effect of Mn on SMA and brain lipid peroxidation.Entities:
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Year: 1999 PMID： 10344601 DOI： 10.1023/a:1021064711866
Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996