Literature DB >> 10342913

Effect of streptozotocin on glutathione and lipid peroxide levels in various tissues of rats.

I Baştar1, S Seçkin, M Uysal, G Aykaç-Toker.   

Abstract

In this study, the effect of streptozotocin (STZ) on lipid peroxidation and glutathione (GSH) content was investigated in the liver, pancreas and kidney of rats. Lipid peroxide levels were significantly increased in homogenates and mitochondrial fractions of the liver, kidney and pancreas after STZ administration. GSH levels in hepatic and pancreatic tissues were decreased but unchanged in the kidney of diabetic rats. GSH content in hepatic mitochondrial fraction was also decreased compared to control group. On the other hand, the destruction of pancreatic beta-cells was also observed histopathologically. Our results indicate that oxidative stress may play an important role in STZ induced diabetes and mitochondrial fraction may be the target in this toxicity.

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Year:  1998        PMID： 10342913

Source DB:  PubMed          Journal:  Res Commun Mol Pathol Pharmacol        ISSN： 1078-0297


  7 in total

1.  Impaired reductive regeneration of ascorbic acid in the Goto-Kakizaki diabetic rat.

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Journal:  Biochem J       Date:  2000-10-15       Impact factor: 3.857

2.  Pancreatic islet-cell viability, functionality and oxidative status remain unaffected at pharmacological concentrations of commonly used antibiotics in vitro.

Authors:  Y Shewade; S Tirth; R R Bhonde
Journal:  J Biosci       Date:  2001-09       Impact factor: 1.826

3.  Hypoglycaemic and biochemical properties of Cnestis ferruginea.

Authors:  Rahmat A Adisa; Mohammed I Choudhary; Elsie O Adewoye; Olufunso O Olorunsogo
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Review 4.  Molecular basis of neuroprotective activities of rasagiline and the anti-Alzheimer drug TV3326 [(N-propargyl-(3R)aminoindan-5-YL)-ethyl methyl carbamate].

Authors:  M B Youdim; M Weinstock
Journal:  Cell Mol Neurobiol       Date:  2001-12       Impact factor: 5.046

5.  Artocarpus communis Forst. root-bark aqueous extract- and streptozotocin-induced ultrastructural and metabolic changes in hepatic tissues of Wistar rats.

Authors:  Stephen O Adewole; John A O Ojewole
Journal:  Afr J Tradit Complement Altern Med       Date:  2007-06-10

Review 6.  Mitochondrial dysfunction in diabetes: from molecular mechanisms to functional significance and therapeutic opportunities.

Authors:  William I Sivitz; Mark A Yorek
Journal:  Antioxid Redox Signal       Date:  2010-04       Impact factor: 8.401

7.  Diabetes-induced changes in glucose synthesis, intracellular glutathione status and hydroxyl free radical generation in rabbit kidney-cortex tubules.

Authors:  K Winiarska; J Drozak; M Wegrzynowicz; T Fraczyk; J Bryla
Journal:  Mol Cell Biochem       Date:  2004-06       Impact factor: 3.396
  7 in total

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