Literature DB >> 10341837

Collagen synthesis in atherosclerosis: too much and not enough.

M D Rekhter1.   

Abstract

Fibrillar collagen is a critical component of atherosclerotic lesions. Uncontrolled collagen accumulation leads to arterial stenosis, while excessive collagen breakdown combined with inadequate synthesis weakens plaques thereby making them prone to rupture. This review discusses cellular sources of collagen synthesis in atherosclerosis, local and systemic factors modulating collagen gene expression, as well as temporal and spatial patterns of collagen production in human and experimental atherosclerotic lesions.

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Year:  1999        PMID： 10341837     DOI： 10.1016/s0008-6363(98)00321-6

Source DB:  PubMed          Journal:  Cardiovasc Res        ISSN： 0008-6363            Impact factor:   10.787


  70 in total

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