Literature DB >> 1034177

Selective breeding of rats for differences in reactivity to alcohol. An approach to an animal model of alcoholism. I. General procedures.

E P Riley, E X Freed, D Lester.   

Abstract

Strains of rats are being developed which have distinct responses in spontaneous locomotor activity to a subhypnotic dose of alcohol. The purpose is to produce one strain in which the injection of a standard dose of alcohol will result in objectively measurable intoxication and a second in which an identical dose will result in virtually no effect.

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Year:  1976        PMID： 1034177     DOI： 10.15288/jsa.1976.37.1535

Source DB:  PubMed          Journal:  J Stud Alcohol        ISSN： 0096-882X


  14 in total

1.  Selective breeding for sensitivity to the anticholinesterase DFP.

Authors:  D H Overstreet; R W Russell; S C Helps; M Messenger
Journal:  Psychopharmacology (Berl)       Date:  1979-09       Impact factor: 4.530

2.  Hypnotic susceptibility to various depressants in rats selected for differential ethanol sensitivity.

Authors:  E P Riley; N R Shapiro; E A Lochry
Journal:  Psychopharmacology (Berl)       Date:  1979-02-28       Impact factor: 4.530

3.  Mouse lines selected for genetic differences in diazepam sensitivity.

Authors:  E J Gallaher; L E Hollister; S E Gionet; J C Crabbe
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

4.  Avoidance behavior in rats selectively bred for differential alcohol sensitivity.

Authors:  N R Shapiro; E P Riley
Journal:  Psychopharmacology (Berl)       Date:  1980       Impact factor: 4.530

5.  Genetic analysis of sensitivity to ethanol-induced depression of motor activity and impairment of swimming in rats.

Authors:  M B Bass; D Lester
Journal:  Behav Genet       Date:  1983-01       Impact factor: 2.805

6.  Factors involved in the differential response to ethanol, barbital and pentobarbital in rats selectively bred for ethanol sensitivity.

Authors:  J M Mayer; J M Khanna; H Kalant; A Chau
Journal:  Psychopharmacology (Berl)       Date:  1982       Impact factor: 4.530

7.  Differential tolerance to pentobarbital in rats bred for differences in alcohol sensitivity.

Authors:  E P Riley; E A Lochry; E X Freed
Journal:  Psychopharmacology (Berl)       Date:  1978-07-06       Impact factor: 4.530

8.  Rats bred for ethanol sensitivity: impairment of swimming by ethanol and pentobarbital.

Authors:  M B Bass; D Lester
Journal:  Psychopharmacology (Berl)       Date:  1979-05-25       Impact factor: 4.530

9.  Differential pharmacological responses to ethanol, pentobarbital and morphine in rats selectively bred for ethanol sensitivity.

Authors:  J M Mayer; J M Khanna; C Kim; H Kalant
Journal:  Psychopharmacology (Berl)       Date:  1983       Impact factor: 4.530

10.  Selective breeding for diisopropyl fluorophosphate-sensitivity: behavioural effects of cholinergic agonists and antagonists.

Authors:  D H Overstreet; R W Russell
Journal:  Psychopharmacology (Berl)       Date:  1982       Impact factor: 4.530
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