BACKGROUND/AIMS: To evaluate prevalence, aetiology, prognosis, and associated neurological and ophthalmological problems in children with cortical visual impairment (CVI). METHODS: The records of 7200 outpatients seen in the paediatric ophthalmology practice over the past 15 years were reviewed in order to compile data concerning CVI. In addition, the authors devised and applied a system for grading visual recovery in order to assess prognosis. RESULTS: CVI occurred in 2.4% of all patients examined. The four most common causes of CVI were perinatal hypoxia (22%), cerebral vascular accident (14%), meningitis (12%), and acquired hypoxia (10%). Most children with CVI had associated neurological abnormalities. The most common were seizures (53%), cerebral palsy (26%) hemiparesis (12%), and hypotonia (5%). Associated ophthalmological problems were esotropia (19%), exotropia (18%), optic nerve atrophy (16%), ocular motor apraxia (15%), nystagmus (11%), and retinal disease (3%). On average, CVI patients improved by two levels as measured by the authors' scale. CONCLUSION: The majority of children with CVI showed at least some recovery. In this group of children, CVI is often accompanied by additional ophthalmological problems and is nearly always associated with other, serious neurological abnormalities.
BACKGROUND/AIMS: To evaluate prevalence, aetiology, prognosis, and associated neurological and ophthalmological problems in children with cortical visual impairment (CVI). METHODS: The records of 7200 outpatients seen in the paediatric ophthalmology practice over the past 15 years were reviewed in order to compile data concerning CVI. In addition, the authors devised and applied a system for grading visual recovery in order to assess prognosis. RESULTS: CVI occurred in 2.4% of all patients examined. The four most common causes of CVI were perinatal hypoxia (22%), cerebral vascular accident (14%), meningitis (12%), and acquired hypoxia (10%). Most children with CVI had associated neurological abnormalities. The most common were seizures (53%), cerebral palsy (26%) hemiparesis (12%), and hypotonia (5%). Associated ophthalmological problems were esotropia (19%), exotropia (18%), optic nerve atrophy (16%), ocular motor apraxia (15%), nystagmus (11%), and retinal disease (3%). On average, CVI patients improved by two levels as measured by the authors' scale. CONCLUSION: The majority of children with CVI showed at least some recovery. In this group of children, CVI is often accompanied by additional ophthalmological problems and is nearly always associated with other, serious neurological abnormalities.
Authors: Lotfi B Merabet; D Luisa Mayer; Corinna M Bauer; Darick Wright; Barry S Kran Journal: Semin Pediatr Neurol Date: 2017-04-10 Impact factor: 1.636
Authors: Hannah Ferentzi; Constanze Pfitzer; Lisa-Maria Rosenthal; Felix Berger; Katharina R L Schmitt; Peter Kramer Journal: J Clin Psychol Med Settings Date: 2019-12
Authors: Daniëlle G M Bosch; F Nienke Boonstra; Claudia Gonzaga-Jauregui; Mafei Xu; Joep de Ligt; Shalini Jhangiani; Wojciech Wiszniewski; Donna M Muzny; Helger G Yntema; Rolph Pfundt; Lisenka E L M Vissers; Liesbeth Spruijt; Ellen A W Blokland; Chun-An Chen; Richard A Lewis; Sophia Y Tsai; Richard A Gibbs; Ming-Jer Tsai; James R Lupski; Huda Y Zoghbi; Frans P M Cremers; Bert B A de Vries; Christian P Schaaf Journal: Am J Hum Genet Date: 2014-01-23 Impact factor: 11.025