| Literature DB >> 10340620 |
P D Williams1, M G Bock, B E Evans, R M Freidinger, S N Gallicchio, M T Guidotti, M A Jacobson, M S Kuo, M R Levy, E V Lis, S R Michelson, J M Pawluczyk, D S Perlow, D J Pettibone, A G Quigley, D R Reiss, C Salvatore, K J Stauffer, C J Woyden.
Abstract
Structure-activity studies on the oxytocin antagonist 1 (L-371,257; Ki = 9.3 nM) have led to the identification of a related series of compounds containing an ortho-trifluoroethoxyphenylacetyl core which are orally bioavailable and have significantly improved potency in vitro and in vivo, e.g., compound 8 (L-374,943; Ki = 1.4 nM).Mesh：
Substances：
Year: 1999 PMID： 10340620 DOI： 10.1016/s0960-894x(99)00181-x
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823