| Literature DB >> 10340614 |
R J Cherney1, L Wang, D T Meyer, C B Xue, E C Arner, R A Copeland, M B Covington, K D Hardman, Z R Wasserman, B D Jaffee, C P Decicco.
Abstract
Several macrocyclic, hydroxamate derivatives were synthesized and evaluated as inhibitors of matrix metalloproteinases (MMPs) and tumour necrosis factor-alpha (TNF-alpha) production. These macrocycles are anti-succinate based inhibitors linked from P1 to P2'. A variety of functionality was installed at the P1-P2' linkage, which gave inhibitors that displayed excellent MMP inhibition and good TNF-alpha suppression.Entities:
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Year: 1999 PMID： 10340614 DOI： 10.1016/s0960-894x(99)00178-x
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823