| Literature DB >> 10340605 |
S D Kuduk1, F F Zheng, L Sepp-Lorenzino, N Rosen, S J Danishefsky.
Abstract
Geldanamycin (GDM) binds to the Hsp90 chaperone protein and causes the degradation of several important signalling proteins. A series of novel estradiol-geldanamycin hybrids has been synthesized and evaluated for their ability to induce the selective degradation of the estrogen receptor (ER). The hybrid compounds are active and more selective than the parent causing degradation of ER and HER2, but not other GDM targets.Entities:
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Year: 1999 PMID： 10340605 DOI： 10.1016/s0960-894x(99)00185-7
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823