| Literature DB >> 10340602 |
M Ohkubo1, K Kojiri, H Kondo, S Tanaka, H Kawamoto, T Nishimura, I Nishimura, T Yoshinari, H Arakawa, H Suda, H Morishima, S Nishimura.
Abstract
6-N-Amino analogues of NB-506 [6-N-formylamino-12,13-dihydro-1,11-dihydroxy-13-(beta-D-glucopyranosyl) -5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione] (3b) were synthesized and tested with respect to topoisomerase inhibition, cytotoxicity and anticancer effects. Among them, a 1,3-dihydroxypropane analogue (J-109,404, 5t) showed more than ten times more potent anticancer activity in MKN-45 human stomach cancer cells implanted in mice than NB-506.Entities:
Mesh：
Substances：
Year: 1999 PMID： 10340602 DOI： 10.1016/s0960-894x(99)00188-2
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823