BACKGROUND: Risk factors for severe radiation pneumonitis, which often spreads beyond treatment portals and may even be bilateral, have not been fully investigated. The purpose of this study was to identify important factors associated with severe radiation pneumonitis. METHODS: 111 cases of primary lung cancer, treated with radiotherapy or chemoradiotherapy, were retrospectively analyzed. RESULTS: Severe radiation pneumonitis occurred in 17 cases (15.3%). The ratio of interstitial change in lungs before radiotherapy and radiotherapy to the contralateral mediastinum with > 40 Gy in the radiation pneumonitis group (RP group) was significantly higher than in patients without radiation pneumonitis (control group) (47.1% vs 5.3%; P < 0.001 and 58.8% vs 27.7%; P = 0.037, respectively). Using logistic regression analysis, interstitial changes before radiotherapy and radiotherapy to the contralateral mediastinum of > 40 Gy were significant risk factors associated with severe radiation pneumonitis. CONCLUSIONS: These data suggest that pre-existing interstitial changes detected by chest radiography or computed tomography and radiotherapy to the contralateral mediastinum (> 40 Gy) may predict the development of severe radiation pneumonitis.
BACKGROUND: Risk factors for severe radiation pneumonitis, which often spreads beyond treatment portals and may even be bilateral, have not been fully investigated. The purpose of this study was to identify important factors associated with severe radiation pneumonitis. METHODS: 111 cases of primary lung cancer, treated with radiotherapy or chemoradiotherapy, were retrospectively analyzed. RESULTS: Severe radiation pneumonitis occurred in 17 cases (15.3%). The ratio of interstitial change in lungs before radiotherapy and radiotherapy to the contralateral mediastinum with > 40 Gy in the radiation pneumonitis group (RP group) was significantly higher than in patients without radiation pneumonitis (control group) (47.1% vs 5.3%; P < 0.001 and 58.8% vs 27.7%; P = 0.037, respectively). Using logistic regression analysis, interstitial changes before radiotherapy and radiotherapy to the contralateral mediastinum of > 40 Gy were significant risk factors associated with severe radiation pneumonitis. CONCLUSIONS: These data suggest that pre-existing interstitial changes detected by chest radiography or computed tomography and radiotherapy to the contralateral mediastinum (> 40 Gy) may predict the development of severe radiation pneumonitis.
Authors: Yun Hee Lee; Yeon Sil Kim; Sang Nam Lee; Hyo Chun Lee; Se Jin Oh; Seoung Joon Kim; Young Kyoon Kim; Dae Hee Han; Ie Ryung Yoo; Jin Hyung Kang; Suk Hee Hong Journal: Cancer Res Treat Date: 2015-02-13 Impact factor: 4.679
Authors: Sebastian Zschaeck; Monique Simon; Steffen Löck; Esther G C Troost; Kristin Stützer; Patrick Wohlfahrt; Steffen Appold; Sebastian Makocki; Rebecca Bütof; Christian Richter; Michael Baumann; Mechthild Krause Journal: Trials Date: 2016-11-15 Impact factor: 2.279
Authors: William Liu; Benjamin M Haley; Mary J Kwasny; Jian-Jian Li; David J Grdina; Tatjana Paunesku; Gayle E Woloschak Journal: Int J Environ Res Public Health Date: 2012-12-18 Impact factor: 3.390
Authors: Richard Castillo; Ngoc Pham; Sobiya Ansari; Dmitriy Meshkov; Sarah Castillo; Min Li; Adenike Olanrewaju; Brian Hobbs; Edward Castillo; Thomas Guerrero Journal: Radiat Oncol Date: 2014-03-13 Impact factor: 3.481