Literature DB >> 1033984

The developmental analysis of an embryonic lethal (C6H) in the mouse.

S E Lewis, H A Turchin, S Gluecksohn-Waelsch.   

Abstract

A development study of the effects of the C6H allele at the albino locus has identified the C6H homozygote as an early postimplantation lethal. Homozygous C6H embryos can first be recognized at 6 1/2-7 days of gestation by abnormalities of the ectoplacental and parietal endodern. At 7 1/2 days, mutant embryos appear severely retarded with obvious abnormalities in all germ layers. All C6H homozygotes are dead and resorbed by 8 days of development. It is proposed that the mutation interferes with the normal differentiation of the parietal endoderm, ectoplacental cone and extra-embryonic ectoderm of the egg cyclinder.

Entities:  

Mesh：

Year:  1976        PMID： 1033984

Source DB:  PubMed          Journal:  J Embryol Exp Morphol        ISSN： 0022-0752


  8 in total

1.  N-ethyl-N-nitrosourea mutagenesis of a 6- to 11-cM subregion of the Fah-Hbb interval of mouse chromosome 7: Completed testing of 4557 gametes and deletion mapping and complementation analysis of 31 mutations.

Authors:  E M Rinchik; D A Carpenter
Journal:  Genetics       Date:  1999-05       Impact factor: 4.562

2.  Molecular mapping within the mouse albino-deletion complex.

Authors:  D K Johnson; R E Hand; E M Rinchik
Journal:  Proc Natl Acad Sci U S A       Date:  1989-11       Impact factor: 11.205

3.  The albino-deletion complex of the mouse: molecular mapping of deletion breakpoints that define regions necessary for development of the embryonic and extraembryonic ectoderm.

Authors:  S K Sharan; B Holdener-Kenny; S Ruppert; A Schedl; G Kelsey; E M Rinchik; T Magnuson
Journal:  Genetics       Date:  1991-11       Impact factor: 4.562

4.  Genomic mapping within the albino-deletion complex using individual early postimplantation mouse embryos.

Authors:  S K Sharan; B Holdener-Kenny; D W Threadgill; T Magnuson
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

5.  Deletion mapping of four loci defined by N-ethyl-N-nitrosourea-induced postimplantation-lethal mutations within the pid-Hbb region of mouse chromosome 7.

Authors:  E M Rinchik; D A Carpenter; C L Long
Journal:  Genetics       Date:  1993-12       Impact factor: 4.562

6.  Molecular analysis of radiation-induced albino (c)-locus mutations that cause death at preimplantation stages of development.

Authors:  E M Rinchik; R R Tönjes; D Paul; M D Potter
Journal:  Genetics       Date:  1993-12       Impact factor: 4.562

7.  Molecular genetics of the brown (b)-locus region of mouse chromosome 4. I. Origin and molecular mapping of radiation- and chemical-induced lethal brown deletions.

Authors:  E M Rinchik; J A Bell; P R Hunsicker; J M Friedman; I J Jackson; L B Russell
Journal:  Genetics       Date:  1994-07       Impact factor: 4.562

8.  A strategy for fine-structure functional analysis of a 6- to 11-centimorgan region of mouse chromosome 7 by high-efficiency mutagenesis.

Authors:  E M Rinchik; D A Carpenter; P B Selby
Journal:  Proc Natl Acad Sci U S A       Date:  1990-02       Impact factor: 11.205
  8 in total

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